Predictive value of cystatin C and beta-2 microglobulin in preeclampsia
| Autor: | Mona K. Farag, Nabila Abd El Maksoud, Halla M. Ragab, Khaled R. Gaber |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
biology
Beta-2 microglobulin business.industry Glomerular endotheliosis Case-control study Renal function medicine.disease Preeclampsia Predictive value female genital diseases and pregnancy complications Andrology Beta-2 microglobulin (B2M) Cystatin C Second trimester biology.protein Gestation Medicine General Materials Science Glomerular filtration rate business reproductive and urinary physiology |
| Zdroj: | Journal of Genetic Engineering and Biotechnology. 9(2):133-136 |
| ISSN: | 1687-157X |
| DOI: | 10.1016/j.jgeb.2011.09.003 |
| Popis: | The purpose of this study was to determine whether the levels of cystatin C and beta-2 microglobulin (B2M) are altered during the second trimester in the plasma of women who subsequently develop preeclampsia. Study design We performed a case control study to compare the levels of cystatin C and B2M in women in whom preeclampsia ultimately developed ( n = 30) and in pregnant women who remained normotensive throughout gestation ( n = 60). The maternal plasma levels of cystatin C and B2M were measured by enzyme-linked immunosorbent assay. Blood samples were collected between 15 and 20 weeks’ gestation for fetal aneuploidy screening and frozen at −20 °C until assay after groups had been selected. Results The median concentrations of cystatin C and B2M were significantly higher in those who subsequently developed preeclampsia when compared to those of normal pregnancy (median 668.6 ng/ml and 418.3 μg/ml vs 413.7 ng/ml and 321.2 μg/ml, respectively). Conclusions In this study, the maternal plasma levels of cystatin C and B2M were significantly elevated in pregnant women who subsequently developed preeclampsia as compared with normotensive women. Alterations of these proteins antedate clinical symptoms and, thus, they may be useful for early identification of patients at the risk of developing preeclampsia. |
| Databáze: | OpenAIRE |
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