ANTIARRHYTHMIC AND MYOCARDIAL METABOLIC EFFEDTS OF VERAPAMIL DURING CORONARY ARTERY REPERFUSION
| Autor: | Terumasa Nishiyama, Masaaki Abe, Akira Kobayashi, Hideharu Hayashi, Tetsuo Yamashita, Bunnosuke Nagao, Kyoichi Ishizaka, Noboru Yamazaki, Tadashi Kamikawa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 1984 |
| Předmět: |
Male
Tachycardia medicine.medical_specialty Long chqin acy1 carnitine Physiology Fatty Acids Nonesterified Ventricular tachycardia chemistry.chemical_compound Adenosine Triphosphate Dogs Ventricular arrhythmias Carnitine Internal medicine medicine Animals cardiovascular diseases Fatty acid metabolism business.industry Myocardium Arrhythmias Cardiac medicine.disease Coronary Vessels Perfusion Endocrinology medicine.anatomical_structure chemistry fatty acid metabolism Verapamil Coronary occlusion Ventricular fibrillation Cardiology cardiovascular system Female Acyl Coenzyme A Coronary reperfusion medicine.symptom Cardiology and Cardiovascular Medicine business medicine.drug Artery |
| Zdroj: | Japanese Circulation Journal. 49(3):316-324 |
| ISSN: | 0047-1828 |
| Popis: | The accumulation of metabolic intermediates subsequent to impaired β-oxidation of free fatty acids has been suggested to be a cause of cellular damage and ventricular arrhythmias in the ischemic heart. The effects of verapamil on ventricular arrhythmias and free fatty acids metabolism during coronary artery reperfusion in experimental dogs were evaluated over a period of 40 minutes and followed by reperfusion for 15 minutes. One tenth mg/kg/min of verapamil was administered for 5 minutes before occlusion and followed by an infusion of 0.01 mg/kg/min to the end of the experiment. Myocardial samples were obtained from both the non-ischemic and ischemic areas after coronary artery reperfusion and then ATP, free carnitine, long chain acyl carnitine and long chain acyl CoA were measured. In the control group, 3 dogs (27%) had ventricular fibrillation and 2 dogs (18%) had ventricular tachycardia during coronary occlusion. In addition, 2 dogs (25%) developed ventricular fibrillation after reperfusion. On the other hand, all 6 dogs treated with verapamil had neither ventricular fibrillation nor tachycardia during both coronary artery occlusion and reperfusion. ATP and free carnitine levels in the ischemic area were significantly higher in the verapamil group than in the control group (ATP: p |
| Databáze: | OpenAIRE |
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