| Autor: |
Pablo Celnik, Wouter Schellekens, Adam B. Cohen, Tessy M. Thomas, Gabriela Cantarero, David P. McMullen, Francesco Tenore, Eric A. Pohlmeyer, Matthew S. Fifer, Nick F. Ramsey, Luke Osborn, Teresa Wojtasiewicz, Brock A. Wester, Sliman J. Bensmaia, Adam Schiavi, Christopher Coogan, Robert W. Nickl, Nathan E. Crone, Daniel N. Candrea, Chad R. Gordon, William S. Anderson |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| DOI: |
10.1101/2020.07.10.20149021 |
| Popis: |
Defining eloquent cortex intraoperatively, traditionally performed by neurosurgeons to preserve patient function, can now help target electrode implantation for restoring function. Brain-machine interfaces (BMIs) have the potential to restore upper-limb motor control to paralyzed patients but require accurate placement of recording and stimulating electrodes to enable functional control of a prosthetic limb. Beyond motor decoding from recording arrays, precise placement of stimulating electrodes in cortical areas associated with finger and fingertip sensations allows for the delivery of sensory feedback that could improve dexterous control of prosthetic hands. In our study, we demonstrated the use of a novel intraoperative online functional mapping (OFM) technique with high-density electrocorticography (ECoG) to localize finger representations in human primary somatosensory cortex. In conjunction with traditional pre- and intraoperative targeting approaches, this technique enabled accurate implantation of stimulating microelectrodes, which was confirmed by post-implantation intra-cortical stimulation of finger and fingertip sensations. This work demonstrates the utility of intraoperative OFM and will inform future studies of closed-loop BMIs in humans. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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