Evaluation of nebulised dexmedetomidine in blunting haemodynamic response to intubation: A prospective randomised study

Autor:	Shibani Padhy, Virinchi Sanapala, Vadithe Vasram Naik, Nirmala Jonnavithula, Nimmagadda R R Kumar
Rok vydání:	2020
Předmět:	Mean arterial pressure premedication medicine.medical_treatment Sedation Laryngoscopy intubation lcsh:RD78.3-87.3 03 medical and health sciences 0302 clinical medicine 030202 anesthesiology medicine Intubation Dexmedetomidine laryngoscopy medicine.diagnostic_test business.industry Tracheal intubation 030208 emergency & critical care medicine Anesthesiology and Pain Medicine sedation lcsh:Anesthesiology Anesthesia Premedication Original Article medicine.symptom business Propofol entropy medicine.drug
Zdroj:	Indian Journal of Anaesthesia Indian Journal of Anaesthesia, Vol 64, Iss 10, Pp 874-879 (2020)
ISSN:	0019-5049
Popis:	Background and Aim: The process of laryngoscopy and endotracheal intubation is associated with intense sympathetic activity, which may precipitate intra-operative complications. Taking the advantage of dexmedetomidine's good bioavailability and rapid absorption through nasal mucosa; we contemplated this study to evaluate the effects of nebulised dexmedetomidine as a premedication in blunting the haemodynamic response to laryngoscopy and tracheal intubation. Methods: This prospective, randomised, comparative study was conducted in 100 American Society of Anesthesiologists (ASA) I, II patients. The primary outcome was to evaluate the effects of dexmedetomidine nebulisation in blunting the stress response to laryngoscopy and intubation. The secondary outcome was to study its adverse effects. The study population was divided randomly into two groups. Control group C (n = 50) received nebulisation with 5 ml of normal saline and group D (n = 50) received 1 μg/kg dexmedetomidine 5 ml 10 min before induction in sitting position. Results: Demographics were comparable. Following laryngoscopy and intubation, systolic (SBP), diastolic (DBP) and mean arterial pressure (MAP), response entropy (RE) and state entropy (SE) were markedly increased in the control group whereas in group D there was a fall in SBP (at 1 min-126.64 ± 26.37; P 0.01, 5 min-109.50 ± 16.83; P 0.02, 10 min-106.94 ± 17.01; P 0.03), DBP (at 1 min-83.18 ± 17.89; P 0.001, 5 min-66.40 ± 13.88; P 0.001, 10 min- 62.56 ± 14.91; P 0.01) and MAP (at 1 min-99.68 ± 19.22; P 0.001, 5 min- 84.08 ± 13.66; P 0.003, 10 min- 81.74 ± 14.79; P 0.008), RE and SE which was statistically significant (P 0.002). There was a dose sparing effect of propofol in group D; sedation score was comparable. Conclusion: Nebulised dexmedetomidine effectively blunts the stress response to laryngoscopy and intubation with no adverse effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd78e3e40270c254f22cfa51605bd793 https://pubmed.ncbi.nlm.nih.gov/33437076 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.