Antioxidative, Antimutagenic, and Anticarcinogenic Activities of Rice Bran Extracts in Chemical and Cell Assays
| Autor: | Mendel Friedman, Seok Hyun Nam, Mi Young Kang, Sun Phil Choi, Nobuyuki Kozukue |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Antioxidant
medicine.medical_treatment HL-60 Cells Antioxidants Chinese hamster Cell Line chemistry.chemical_compound Cricetulus Cricetinae medicine Animals Anticarcinogenic Agents Humans Lung B-Lymphocytes Bran biology Plant Extracts Superoxide food and beverages Antimutagenic Agents Callithrix Oryza Biological activity Free Radical Scavengers General Chemistry biology.organism_classification chemistry Biochemistry Seeds Phorbol Brown rice Lipid Peroxidation Rabbits General Agricultural and Biological Sciences Antimutagen |
| Zdroj: | Journal of Agricultural and Food Chemistry. 53:816-822 |
| ISSN: | 1520-5118 0021-8561 |
| DOI: | 10.1021/jf0490293 |
| Popis: | Ethanol-water (70:30 v/v) extracts from rice brans removed from seeds of two blackish-purple pigmented (Sanhaehyanghyulla and Suwon 415) and one nonpigmented (Chuchung) brown rice cultivars were evaluated for antioxidative, anti-tumor-promoting, and anticarcinogenic activities in chemical assays and in mammalian cells (human leukemia HL-60, marmoset B lymphoblastoid B95-8, and Chinese hamster V79 lung cells) by the following tests: inhibition of xanthine oxidase activity; chelation of ferrous ions; reduction of potassium ferricyanide; scavenging of superoxide anions, hydroxyl radicals, and intracellular peroxides; inhibition of 4-nitroquinoline N-oxide-induced mutagenesis; and inhibition of phorbol ester-induced tumor promotion. The extracts from the pigmented rice seeds had generally higher activities in all tests than did the extract from the nonpigmented variety. The results suggest that brans from pigmented rice varieties may provide a source of new natural antioxidants and anticarcinogens and that such rice cultivars with high antioxidative potential also provide a genetic resource for the development of new, improved rice cultivars that may make it possible to enhance both the nutritional and medical value of rice-based diets. |
| Databáze: | OpenAIRE |
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