Identification of a novel human homolog of theDrosophiladlg, P-dlg, specifically expressed in the gland tissues and interacting with p55
| Autor: | Hideo Nakamura, Hideaki Miyake, Tamotsu Sudo, Norio Masuko, Yukitaka Ushio, Ji Ichiro Sasaki, Masato Kochi, Hideyuki Saya, Hiromasa Tsuiki, Tetsuro Morisaki |
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| Rok vydání: | 1998 |
| Předmět: |
Male
Vesicle-associated membrane protein 8 p55 Tumor suppressor gene Blotting Western Molecular Sequence Data Biophysics Gene Expression Biology Biochemistry P-dlg MAGUK family protein Structural Biology Genetics Extracellular Animals Drosophila Proteins Humans Genes Tumor Suppressor Amino Acid Sequence RNA Messenger Cytoskeleton Molecular Biology Cells Cultured Epithelial polarity Chromosomes Human Pair 10 Cell growth Tumor Suppressor Proteins fungi Prostate Chromosome Mapping Membrane Proteins Cell Biology Blotting Northern Peptide Fragments Cell biology Membrane protein Organ Specificity Cytoplasm Insect Proteins Drosophila Carrier Proteins Nucleoside-Phosphate Kinase Guanylate Kinases Chromosome 10q23 |
| Zdroj: | FEBS Letters. 433:63-67 |
| ISSN: | 0014-5793 |
| DOI: | 10.1016/s0014-5793(98)00882-5 |
| Popis: | We have identified a novel human homolog of the Drosophila dlg tumor suppressor gene, termed P-dlg, which has been mapped at chromosome 10q23. Unlike other human dlg homologs, P-dlg is expressed in placenta and various gland tissues but not in brain. The P-dlg protein is localized at the plasma membrane and cytoplasm, and it is expressed in the gland epithelial cells in normal prostate tissue but not in prostate cancer cell lines. Furthermore, we identified interaction between P-dlg and p55 palmitoylated membrane protein by yeast two-hybrid screening. These findings suggest that P-dlg forms a complex with p55 at the plasma membrane and plays roles in maintaining the structure of epithelial cells and transmitting extracellular signals to the membrane and cytoskeleton, which may negatively regulate cell proliferation. |
| Databáze: | OpenAIRE |
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