Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial
| Autor: | Anders, Widmark, Olbjørn, Klepp, Arne, Solberg, Jan-Erik, Damber, Anders, Angelsen, Per, Fransson, Jo-Asmund, Lund, Ilker, Tasdemir, Morten, Hoyer, Fredrik, Wiklund, Sophie D, Fosså, R, Kalsnes |
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| Rok vydání: | 2008 |
| Předmět: |
Oncology
Male medicine.medical_specialty medicine.medical_treatment Severity of Illness Index law.invention Prostate cancer Randomized controlled trial law Internal medicine Medicine Endocrine system Humans Cumulative incidence Aged Prostatectomy business.industry Cancer Prostatic Neoplasms Androgen Antagonists General Medicine medicine.disease Combined Modality Therapy Survival Analysis Flutamide Radiation therapy Relative risk business |
| Zdroj: | Widmark, A, Klepp, O, Solberg, A, Damber, J-E, Angelsen, A, Fransson, P, Lund, J-A, Tasdemir, I, Høyer, M, Wiklund, F & Fosså, S D 2009, ' Endocrine treatment, with or without radiotherapy, in locally advanced prostate cancer (SPCG-7/SFUO-3): an open randomised phase III trial ', Lancet, vol. 373, no. 9660, pp. 301-8 . https://doi.org/10.1016/S0140-6736(08)61815-2 |
| ISSN: | 1474-547X |
| DOI: | 10.1016/S0140-6736(08)61815-2 |
| Popis: | SummaryBackgroundSeveral studies have shown the efficacy of endocrine therapy in combination with radiotherapy in high-risk prostate cancer. To assess the effect of radiotherapy, we did an open phase III study comparing endocrine therapy with and without local radiotherapy, followed by castration on progression.MethodsThis randomised trial included men from 47 centres in Norway, Sweden, and Denmark. Between February, 1996, and December, 2002, 875 patients with locally advanced prostate cancer (T3; 78%; PSA |
| Databáze: | OpenAIRE |
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