Sex differences in solid pseudopapillary neoplasm of the pancreas: A population‐based study
Autor: | Yiquan Jiang, Yize Mao, Yunda Song, Shuxin Sun, Shengping Li, Ping Yu, Jiali Wu |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Adult Male Cancer Research medicine.medical_specialty medicine.medical_treatment hormone Kaplan-Meier Estimate Gastroenterology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine Rare Diseases Sex Factors Internal medicine medicine Humans Radiology Nuclear Medicine and imaging Stage (cooking) Age of Onset Survival analysis Original Research Aged Proportional hazards model business.industry Incidence (epidemiology) Middle Aged Prognosis lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens Carcinoma Papillary Tumor Burden Pancreatic Neoplasms Survival Rate SEER solid pseudopapillary neoplasm of the pancreas Dissection 030104 developmental biology Lymphatic system medicine.anatomical_structure Oncology sex‐related discrepancy 030220 oncology & carcinogenesis Lymph Node Excision Regression Analysis Female Hormone therapy business Pancreas Cancer Prevention |
Zdroj: | Cancer Medicine, Vol 9, Iss 16, Pp 6030-6041 (2020) Cancer Medicine |
ISSN: | 2045-7634 |
Popis: | Objective Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor. This study aims to examine the clinicopathological features and surgical treatments of SPN and compare the clinical behavior and prognosis between men and women with SPN. Methods We collected the population data of patients with SPN diagnosed between 2004 and 2017 from the SEER database. The Kaplan‐Meier method was used to analyze overall survival (OS) and disease‐specific survival (DSS), and log‐rank tests were used to evaluate the differences between subgroups. Univariate and multivariate Cox regression analyses were performed to screen out prognostic risk factors of SPN. Results A total of 378 patients with SPN were included, with 246 (65.1%) female patients. 1‐, 3‐, and 5‐year overall survival rates were 98.9%, 95.7%, and 93.7%, respectively. Survival analysis revealed that regardless of stage, patients with SPN who underwent surgical interventions still had a significantly better prognosis than those without surgical interventions (P Our study is the first large enough study to emphasize the sex‐related discrepancies in solid pseudopapillary neoplasm (SPN), and to observe that clinicopathological characteristic profiles were more common for male SPN and postmenopausal female SPN. It may provide inspiration for different management strategies for male and female patients and imply the possibility of hormone therapy for SPN. |
Databáze: | OpenAIRE |
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