Sex differences in solid pseudopapillary neoplasm of the pancreas: A population‐based study

Autor: Yiquan Jiang, Yize Mao, Yunda Song, Shuxin Sun, Shengping Li, Ping Yu, Jiali Wu
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Adult
Male
Cancer Research
medicine.medical_specialty
medicine.medical_treatment
hormone
Kaplan-Meier Estimate
Gastroenterology
lcsh:RC254-282
03 medical and health sciences
0302 clinical medicine
Rare Diseases
Sex Factors
Internal medicine
medicine
Humans
Radiology
Nuclear Medicine and imaging
Stage (cooking)
Age of Onset
Survival analysis
Original Research
Aged
Proportional hazards model
business.industry
Incidence (epidemiology)
Middle Aged
Prognosis
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Carcinoma
Papillary
Tumor Burden
Pancreatic Neoplasms
Survival Rate
SEER
solid pseudopapillary neoplasm of the pancreas
Dissection
030104 developmental biology
Lymphatic system
medicine.anatomical_structure
Oncology
sex‐related discrepancy
030220 oncology & carcinogenesis
Lymph Node Excision
Regression Analysis
Female
Hormone therapy
business
Pancreas
Cancer Prevention
Zdroj: Cancer Medicine, Vol 9, Iss 16, Pp 6030-6041 (2020)
Cancer Medicine
ISSN: 2045-7634
Popis: Objective Solid pseudopapillary neoplasm (SPN) of the pancreas is a rare tumor. This study aims to examine the clinicopathological features and surgical treatments of SPN and compare the clinical behavior and prognosis between men and women with SPN. Methods We collected the population data of patients with SPN diagnosed between 2004 and 2017 from the SEER database. The Kaplan‐Meier method was used to analyze overall survival (OS) and disease‐specific survival (DSS), and log‐rank tests were used to evaluate the differences between subgroups. Univariate and multivariate Cox regression analyses were performed to screen out prognostic risk factors of SPN. Results A total of 378 patients with SPN were included, with 246 (65.1%) female patients. 1‐, 3‐, and 5‐year overall survival rates were 98.9%, 95.7%, and 93.7%, respectively. Survival analysis revealed that regardless of stage, patients with SPN who underwent surgical interventions still had a significantly better prognosis than those without surgical interventions (P
Our study is the first large enough study to emphasize the sex‐related discrepancies in solid pseudopapillary neoplasm (SPN), and to observe that clinicopathological characteristic profiles were more common for male SPN and postmenopausal female SPN. It may provide inspiration for different management strategies for male and female patients and imply the possibility of hormone therapy for SPN.
Databáze: OpenAIRE
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