Vesico-ureteric reflux in adults with neuropathic bladders treated with Polydimethylsiloxane (Macroplastique®)
| Autor: | S Avenell, T. Lane, P.J.R. Shah, M. J. Kabir, N.C. Shah |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male medicine.medical_specialty Silicones Neurological disorder urologic and male genital diseases Vesicoureteral reflux Injections Ureter Recurrence medicine Humans Dimethylpolysiloxanes Urinary Bladder Neurogenic Aged Aged 80 and over Vesico-Ureteral Reflux medicine.diagnostic_test business.industry Reflux General Medicine Middle Aged medicine.disease Endoscopy Surgery Treatment Outcome medicine.anatomical_structure Neurology Macroplastique Retreatment Female Neurology (clinical) Implant Complication business |
| Zdroj: | Spinal Cord. 39:92-96 |
| ISSN: | 1476-5624 1362-4393 |
| DOI: | 10.1038/sj.sc.3101090 |
| Popis: | Objective: To establish the efficacy of Macroplastique® in treating vesico-ureteric reflux (VUR) in adults with neuropathic bladder dysfunction. Patients and methods: Fifteen patients (12 male and three female), age range 19 to 80 years (mean age 38) were included in this study. Diagnosis was confirmed by videourodynamics. In seven patients reflux was present bilaterally. Twenty-two refluxing ureters were treated. Twelve patients had detrusor hyper-reflexia, two had areflexic bladders and one had loss of bladder wall compliance. According to the International Grading System, 10 ureters had grade IV reflux, five had grade III reflux, five had grade II reflux, and two had grade I reflux. Macroplastique® (0.5–1.5 ml) was injected submucosally under each ureteric orifice to convert the opening to a slit like shape. The patients were followed up from 9 to 68 months. Results: VUR was completely resolved in 72.7% (16) ureters following a single injection and in a further 4.5% (1) ureter following a second injection. 9.1% (2) ureters were improved and treatment failed in 13.7% (3) ureters. Two patients showed a recurrence of reflux 1 and 4 years after primary injection and subsequently had a curative second injection. Most of the patients in whom VUR was cured or improved showed a reduction in laboratory proven urinary infection rates. Conclusion: Macroplastique® produced an excellent result (86% with complete resolution or improvement of reflux) in treating VUR in adult neuropathic bladders. This is comparable to larger studies carried out on the paediatric population. This is an easy procedure, which avoids major surgery and can be performed as a day case. In cases of failure or recurrence, repeat injection or open surgery can be undertaken without any added complications. Spinal Cord (2001) 39, 92–96. |
| Databáze: | OpenAIRE |
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