Aggravating effect of atorvastatin on indomethacin-induced gastric injury: Focus on PGE2, TNF-α, neutrophils and iNOS
| Autor: | Osman Özdemir, Sönmez Uydeş-Doğan, Koray Gumustas, Hande Özyoğurtçu, Özge Uyanik, F. İlkay Alp Yildirim, Aydın Gürel, Pinar Atukeren |
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| Rok vydání: | 2015 |
| Předmět: |
Male
Benzylamines Antioxidant Physiology Neutrophils medicine.medical_treatment Atorvastatin Indomethacin Amidines Mevalonic Acid Nitric Oxide Synthase Type II Pharmacology Biochemistry Dinoprostone Proinflammatory cytokine chemistry.chemical_compound medicine Animals Stomach Ulcer business.industry Tumor Necrosis Factor-alpha Drug Synergism Cell Biology Glutathione medicine.disease digestive system diseases Rats chemistry Neutrophil Infiltration Anesthesia lipids (amino acids peptides and proteins) Gastric injury Tumor necrosis factor alpha Female Mevalonate pathway business Infiltration (medical) medicine.drug |
| Zdroj: | Prostaglandinsother lipid mediators. 121 |
| ISSN: | 1098-8823 |
| Popis: | Statins are suggested to possess healing properties due to their antioxidant and antiinflammatory effects in animal ulcer models. In contrary, a clinical report indicated the formation of gastric ulcer by the use of atorvastatin. In this study, we aimed to investigate the effects of atorvastatin (0.5, 5 and 50mg/kg, p.o.) after single (acute) and multiple (subchronic, 5 days) applications on indomethacin-induced gastric ulcer in rats. In both acute and subchronic models high dose atorvastatin (50mg/kg), unlike to lower doses (0,5 and 5mg/kg), significantly aggravated ulcer lesions induced by indomethacin (30 mg/kg) although, a direct ulcerogenic influence was lacking. Proulcerogenic effect of atorvastatin are likely to be associated with decreased mucosal defense mechanisms (GSH and PGE2), and increased neutrophil infiltration and proinflammatory factors (TNF-a and iNOS) possibly via independently from mevalonate pathway. Thus, atorvastatin therapy should be monitorized in patients for an increased risk of gastric ulcer particularly when used concomitantly with NSAIDs. |
| Databáze: | OpenAIRE |
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