Combined treatment with temporary short-term high dose rate Iridium-192 brachytherapy and external beam radiotherapy for irradiation of localized prostatic carcinoma
| Autor: | Goran Borghede, S. Pettersson, Frank Aldenborg, Sten Holmäng, Göran Sernbo, Karl Axel Johansson, Arne Wallgren, Hans Hedelin, Claes Mercke |
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| Rok vydání: | 1997 |
| Předmět: |
Male
Oncology medicine.medical_specialty Gastrointestinal Diseases medicine.medical_treatment Brachytherapy Prostate cancer Internal medicine Biopsy medicine Carcinoma Humans Radiology Nuclear Medicine and imaging External beam radiotherapy Stage (cooking) Radiation Injuries Aged Neoplasm Staging Dose-Response Relationship Drug medicine.diagnostic_test business.industry Penile Erection Prostatic Neoplasms Hematology Rectal examination Middle Aged Prostate-Specific Antigen Iridium Radioisotopes Urination Disorders medicine.disease Radiation therapy Treatment Outcome business Nuclear medicine |
| Zdroj: | Radiotherapy and Oncology. 44:237-244 |
| ISSN: | 0167-8140 |
| DOI: | 10.1016/s0167-8140(97)00121-7 |
| Popis: | Purpose : To evaluate the treatment outcome after radical radiotherapy of localized prostate cancer in 50 patients (38 patients with stage T1–2 and 12 patients with stage T3) after a median follow-up time of 45 months (range 18–92 months). Methods : The treatment was given by combination of external beam radiotherapy (50 Gy) and brachytherapy (2 × 10 Gy). The brachytherapy was given using TRUS-guided percutaneously inserted temporary needles with a high dose rate remote afterloading technique with Ir-192 as the radionuclide source. Three target definitions and dose levels inside the prostate gland were used. Local control was evaluated by digital rectal examination, TRUS-guided biopsies and serum PSA evaluations. Results : Clinical and biopsy verified local control was achieved in 48 of the 50 (96%) patients; for stage T1–2 in 37 of 38 (97%) patients and for stage T3 in 11 of 12 (92%) patients. A posttreatment serum PSA level ≤1.0 ng/ml was seen in 42 (84%) patients, values from >1.0 to ≤2.0 ng/ml were seen in four (8%) patients and values exceeding 2.0 were seen in four (8%) patients. The late toxicity was minimal. Conclusion : The local control results and the minimal toxicity after the combined radiotherapy treatment are promising. However, long term results are necessary before general use. |
| Databáze: | OpenAIRE |
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