Resveratrol Protects Against Pathological Preterm Birth by Suppression of Macrophage-Mediated Inflammation
| Autor: | Mari Hoya, Takahiro Yamashita, Haruka Nishida, Mitsuyo Yoshida, Ayumi Taguchi, Aki Yamashita, Kazunori Nagasaka, Masakazu Sato, Tomoyuki Fujii, Kei Kawana, Osamu Wada-Hiraike, Eri Inoue, Hiroe Nakamura, Yutaka Osuga, Asaha Fujimoto, Hitomi Furuya, Tomoko Inoue, Takeshi Nagamatsu, Katsuyuki Adachi |
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| Rok vydání: | 2015 |
| Předmět: |
Lipopolysaccharides
medicine.medical_specialty Time Factors endocrine system diseases Lipopolysaccharide Interleukin-1beta Anti-Inflammatory Agents Gestational Age Inflammation Resveratrol Proinflammatory cytokine chemistry.chemical_compound Pregnancy Internal medicine Stilbenes Animals Medicine Macrophage Cells Cultured biology Tumor Necrosis Factor-alpha business.industry organic chemicals food and beverages Obstetrics and Gynecology Interleukin Mice Inbred C57BL Disease Models Animal Endocrinology chemistry Cyclooxygenase 2 Immunology Macrophages Peritoneal biology.protein Premature Birth Female Tumor necrosis factor alpha Cyclooxygenase Inflammation Mediators medicine.symptom business |
| Zdroj: | Reproductive Sciences. 22:1561-1568 |
| ISSN: | 1933-7205 1933-7191 |
| DOI: | 10.1177/1933719115589413 |
| Popis: | Inflammatory cytokines play a major role in spontaneous preterm birth. Resveratrol has strong anti-inflammatory effects, but its effect on preterm birth in vivo is unknown. We investigated whether resveratrol protects against preterm birth in the lipopolysaccharide (LPS)-induced preterm mouse model. Twelve-day-old pregnant mice were fed 20 to 40 mg/kg resveratrol daily. On day 15, 10 μg of LPS was injected into uterine cervices. Resveratrol administration significantly decreased the rate of preterm birth. Resveratrol administration abolished LPS-induced elevation of tumor necrosis factor α (TNF-α) and interleukin (IL) 1β but not IL-6 levels. The TNF-α messenger RNA levels were decreased in the cervices of resveratrol-administered mice compared with controls. Resveratrol treatment suppressed the elevation in TNF-α and IL-1β levels in LPS-exposed peritoneal macrophages. Further resveratrol treatment eradicated the proinflammatory cytokine-mediated elevation in cyclooxygenase 2 (COX-2) in peritoneal macrophages. Resveratrol may protect against pathological preterm birth by suppression of elevated proinflammatory cytokines and consequent elevation of COX-2 in macrophages. |
| Databáze: | OpenAIRE |
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