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Krzewicka-Romaniuk Ewa, Siedlecka Dagna, Pradiuch Anna, Wójcicka Grażyna. Major causes of insuline resistance. Journal of Education, Health and Sport. 2019;9(9):946-952. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.3461607 http://ojs.ukw.edu.pl/index.php/johs/article/view/7497 The journal has had 5 points in Ministry of Science and Higher Education parametric evaluation. § 8. 2) and § 12. 1. 2) 22.02.2019. © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 25.08.2019. Revised: 31.08.2019. Accepted: 22.09.2019. Major causes of insuline resistance Ewa Krzewicka-Romaniuk1, Dagna Siedlecka1, Anna Pradiuch1, Grażyna Wójcicka1 1Department of Pathophysiology, Medical University of Lublin, Lublin, Poland INTRODUCTION The metabolic syndrome is also called insulin resistance syndrome.1 This term was used for the first time in 1922 to describe the few cases of patients with diabetes who required increasing doses of insulin to maintain normoglycemia. Most of these patients developed insulin resistance secondary to the production of antibodies directed against exogenous insulin, which was not sufficiently purified at the time, and what is more, it was obtained from other animal species.2 Insulin resistance is currently defined as the body's insufficient response to specific insulin levels. The clinical spectrum of insulin resistance is broad and includes both diabetic patients who require insulin therapy and experience hyperglycemia despite high doses of exogenous insulin, as well as patients with severe insulin resistance who maintain almost normal blood glucose levels due to significantly higher endogenous insulin secretion.3 Causes of insulin resistance can be divided into innate and secondary.3 There are many reasons for insulin resistance, including genetic mutations like insulin receptor mutations, hormonal and pharmacological or immunological. However, insulin resistance is most commonly associated with obesity.4 |
