Secondary bacterial infections and antimicrobial resistance in COVID-19: comparative evaluation of pre-pandemic and pandemic-era, a retrospective single center study
| Autor: | Feriha Cilli, Melike Yaşar-Duman, Alper Tünger, Şöhret Aydemir, Volkan Özenci, Mustafa Karataş |
|---|---|
| Přispěvatelé: | Yaşar-Duman, Melike, Tünger, Alper, Çilli, Feriha, Aydemir, Şöhret, Özenci, Volkan |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Turkey Infectious and parasitic diseases RC109-216 Drug resistance Antimicrobial resistance Increase Medical microbiology Pandemic Epidemiology Child Aged 80 and over Coinfection Bacterial Infections General Medicine Middle Aged Antimicrobial QR1-502 Anti-Bacterial Agents Infectious Diseases COVID-19 Nucleic Acid Testing Child Preschool Female Adult Microbiology (medical) medicine.medical_specialty Adolescent RM1-950 Microbial Sensitivity Tests Microbiology Young Adult Antibiotic resistance Internal medicine Drug Resistance Bacterial medicine Humans Aged Retrospective Studies Co-infections business.industry Predictors Research Infant COVID-19 Retrospective cohort study Outbreak medicine.disease Secondary bacterial infections Therapeutics. Pharmacology business |
| Zdroj: | Annals of Clinical Microbiology and Antimicrobials Annals of Clinical Microbiology and Antimicrobials, Vol 20, Iss 1, Pp 1-8 (2021) |
| Popis: | Purpose In this study, we aimed to evaluate the epidemiology and antimicrobial resistance (AMR) patterns of bacterial pathogens in COVID-19 patients and to compare the results with control groups from the pre-pandemic and pandemic era. Methods Microbiological database records of all the COVID-19 diagnosed patients in the Ege University Hospital between March 15, 2020, and June 15, 2020, evaluated retrospectively. Patients who acquired secondary bacterial infections (SBIs) and bacterial co-infections were analyzed. Etiology and AMR data of the bacterial infections were collected. Results were also compared to control groups from pre-pandemic and pandemic era data. Results In total, 4859 positive culture results from 3532 patients were analyzed. Fifty-two (3.59%) patients had 78 SBIs and 38 (2.62%) patients had 45 bacterial co-infections among 1447 COVID-19 patients. 22/85 (25.88%) patients died who had bacterial infections. The respiratory culture-positive sample rate was 39.02% among all culture-positive samples in the COVID-19 group. There was a significant decrease in extended-spectrum beta-lactamase (ESBL)-producing Enterobacterales (8.94%) compared to samples from the pre-pandemic (20.76%) and pandemic era (20.74%) (p = 0.001 for both comparisons). Interestingly, Acinetobacter baumannii was the main pathogen in the respiratory infections of COVID-19 patients (9.76%) and the rate was significantly higher than pre-pandemic (3.49%, p < 0.002) and pandemic era control groups (3.11%, p < 0.001). Conclusion Due to the low frequency of SBIs reported during the ongoing pandemic, a more careful and targeted antimicrobial prescription should be taken. While patients with COVID-19 had lower levels of ESBL-producing Enterobacterales, the frequency of multidrug-resistant (MDR) A. baumannii is higher. Karolinska Institute Open access funding provided by Karolinska Institute. The author(s) received no specific funding for this work. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|