Statin-Associated Necrotizing Myopathy Leading to Acute Kidney Injury: A Case Report
| Autor: | Tadej Petreski, Radovan Hojs, Timotej Petrijan, Nejc Piko, Benjamin Dvoršak, Sebastjan Bevc |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Statin medicine.drug_class medicine.medical_treatment Single Case Disease Gastroenterology Pathogenesis Internal medicine medicine Rosuvastatin Renal replacement therapy Kidney business.industry necrotizing myopathy statin Acute kidney injury medicine.disease Diseases of the genitourinary system. Urology medicine.anatomical_structure acute kidney injury Nephrology rhabdomyolysis high cutoff hemodialysis RC870-923 business Rhabdomyolysis medicine.drug |
| Zdroj: | Case Reports in Nephrology and Dialysis, Vol 11, Iss 2, Pp 129-135 (2021) Case Reports in Nephrology and Dialysis |
| ISSN: | 2296-9705 |
| Popis: | Statins or 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors are a mainstay of cardiovascular disease therapy. In addition to their lipid-lowering capabilities, they exhibit several pleiotropic effects. Their adverse reactions such as myalgias are not uncommon, but in rare cases, the resulting rhabdomyolysis can be fatal. Recently, more insight has been brought into the pathogenesis of statin-induced rhabdomyolysis, and immune-mediated necrotizing myopathies are diagnosed more frequently. We present a case of a female patient who was on chronic rosuvastatin therapy and developed necrotizing myopathy. The disease progressed to acute kidney and liver injury. We discontinued the drug, started supportive measures, and initiated renal replacement therapy with a high cutoff dialysis membrane once. Her recovery was prompt, with a normal control electromyography 2 weeks after discharge. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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