Platelet activation and aggregation profile in prolonged external ventricular support
| Autor: | Rémi Houël, Emmanuelle Vermes, Ludovic Drouet, Daniel Loisance, Bernadette Boval, Mathias Kirsch, Elisabeth Mazoyer |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.medical_specialty Time Factors Adolescent Platelet Aggregation Fibrinogen Endothelial activation chemistry.chemical_compound Von Willebrand factor Internal medicine medicine Humans Platelet Prospective Studies Platelet activation Aspirin biology business.industry Middle Aged Platelet Activation Adenosine diphosphate Endocrinology chemistry Anesthesia biology.protein Female Surgery Heart-Assist Devices Cardiology and Cardiovascular Medicine business Platelet Aggregation Inhibitors Ex vivo medicine.drug |
| Zdroj: | The Journal of Thoracic and Cardiovascular Surgery. 128:197-202 |
| ISSN: | 0022-5223 |
| DOI: | 10.1016/j.jtcvs.2003.11.059 |
| Popis: | Background Platelet function plays a major role in the understanding of thromboembolic events in prolonged mechanical support. We studied the platelet activation, platelet aggregation profile, and efficacy of aspirin in patients in whom an external ventricular assist device had been implanted. Patients and methods Fifteen patients were studied prospectively up to 6 weeks after implantation of the same type of ventricular assist device. Platelet function was studied weekly before daily aspirin administration. Aspirin efficacy was tested ex vivo by measuring platelet aggregation triggered by arachidonic acid. Flow cytometry was used to quantify the spontaneous and induced (adenosine diphosphate stimulation) expression of glycoproteins αIIbβ3, Ibα, and CD62P on platelet membranes. The plasma levels of von Willebrand factor (von Willebrand factor activity and von Willebrand factor antigen) and fibrinogen were also determined. Results Six of the 15 patients (26%) maintained an arachidonic acid-induced platelet aggregation despite daily aspirin treatment (250 mg). CD62P values remained increased during a 5-week postoperative period. Spontaneous levels of glycoproteins αIIbβ3 and Ibα on platelet membranes remained within a normal range with a preserved reactivity. The plasma levels of fibrinogen and von Willebrand factor remained increased during the entire study period. Conclusion In patients with an implanted external ventricular assist device, the platelet activation profile displays a persistent activation with a preserved reactivity associated with a persistent high inflammatory state and endothelial activation. |
| Databáze: | OpenAIRE |
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