Daily Adaptive Proton Therapy: Is it Appropriate to Use Analytical Dose Calculations for Plan Adaption?
| Autor: | Carla Winterhalter, Michael Matter, Francesca Albertini, Antony J. Lomax, Damien C. Weber, Lena Nenoff, Agnes Geetanjali Jarhall, Mirjana Josipovic, Gitte F. Persson, Jenny Gorgisyan, Per Munck af Rosenschöld |
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| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
Lung Neoplasms Dose calculation Monte Carlo method Dose distribution computer.software_genre Radiation Dosage 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Voxel Carcinoma Non-Small-Cell Lung Proton Therapy Initial treatment Medicine Humans Radiology Nuclear Medicine and imaging Head and neck Proton therapy Radiation business.industry Radiotherapy Planning Computer-Assisted Radiotherapy Dosage Oncology 030220 oncology & carcinogenesis Non small cell Nuclear medicine business computer Monte Carlo Method |
| Zdroj: | Nenoff, L, Matter, M, Jarhall, A G, Winterhalter, C, Gorgisyan, J, Josipovic, M, Persson, G F, Munck af Rosenschold, P, Weber, D C, Lomax, A J & Albertini, F 2020, ' Daily Adaptive Proton Therapy : Is it Appropriate to Use Analytical Dose Calculations for Plan Adaption? ', International Journal of Radiation Oncology Biology Physics, vol. 107, no. 4, pp. 747-755 . https://doi.org/10.1016/j.ijrobp.2020.03.036 |
| ISSN: | 1879-355X |
| DOI: | 10.1016/j.ijrobp.2020.03.036 |
| Popis: | Purpose: The accuracy of analytical dose calculations (ADC) and dose uncertainties resulting from anatomical changes are both limiting factors in proton therapy. For the latter, rapid plan adaption is necessary; for the former, Monte Carlo (MC) approaches are increasingly recommended. These, however, are inherently slower than analytical approaches, potentially limiting the ability to rapidly adapt plans. Here, we compare the clinical relevance of uncertainties resulting from both. Methods and Materials: Five patients with non-small cell lung cancer with up to 9 computed tomography (CT) scans acquired during treatment and five paranasal (head and neck) patients with 10 simulated anatomical changes (sinus filling) were analyzed. On the initial planning CT scans, treatment plans were optimized and calculated using an ADC and then recalculated with MC. Additionally, all plans were recalculated (non-adapted) and reoptimized (adapted) on each repeated CT using the same ADC as for the initial plan, and the resulting dose distributions were compared. Results: When comparing analytical and MC calculations in the initial treatment plan and averaged over all patients, 94.2% (non-small cell lung cancer) and 98.5% (head and neck) of voxels had differences |
| Databáze: | OpenAIRE |
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