Peripheral Blood Biomarkers Coupled with the Apolipoprotein E4 Genotype are Strongly Associated with Semantic and Episodic Memory Impairments in Elderly Subjects with Amnestic Mild Cognitive Impairment and Alzheimer’s Dementia
| Autor: | Itthipol Tawankanjanachot, Thiti Snabboon, Chavit Tunvirachaisakul, Thitiporn Supasitthumrong, Sookjaroen Tangwongchai, Daruj Aniwattanapong, Phenphichcha Chuchuen, Michael Maes, Solaphat Hemrungrojn, André F. Carvalho |
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| Rok vydání: | 2019 |
| Předmět: |
Apolipoprotein B
biology business.industry medicine_pharmacology_behavioral_neuroscience Inflammation medicine.disease Peripheral blood mental disorders Immunology Genotype medicine biology.protein Dementia lipids (amino acids peptides and proteins) Alzheimer s dementia Apolipoprotein e4 medicine.symptom business Episodic memory |
| DOI: | 10.20944/preprints201901.0296.v1 |
| Popis: | Background: The Apolipoprotein E4 (ApoE4) genotype is strongly associated with Alzheimer’s disease (AD), although the presence of the ApoE4 allele alone is not sufficient to explain AD. The pathophysiology of amnestic mild cognitive impairment (aMCI) remains unclear. This study aims to examine associations between peripheral blood biomarkers coupled with ApoE4 and episodic and semantic memory.Methods: The CERAD battery was completed and various biomarkers were assayed in 60 subjects with aMCI, 60 with AD and 62 healthy controls.Results: Deficits in semantic and episodic memory were significantly predicted by anion gap and bicarbonate, albumin and glucose coupled with Apo E4. Furthermore, these peripheral biomarkers interacted with ApoE to predict greater memory impairments.Conclusions: Peripheral blood biomarkers may interact with pathways related to ApoE4 to predict greater semantic and episodic memory impairments, thus contributing to the pathophysiology of aMCI and AD. Our data suggest that the transition from aMCI to AD could at least in some cases be associated with significant interactions between ApoE4 and those peripheral blood biomarkers. |
| Databáze: | OpenAIRE |
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