Expression changes of multiple brain-derived neurotrophic factor transcripts in selective spinal nerve ligation model and complete Freund's adjuvant model
| Autor: | Rhuji Kaku, Megumi Omori, Masataka Yokoyama, Hiroyuki Kobayashi, Yoshitaro Itano, Kiyoshi Morita, Hiroyuki Ichikawa, Yoshikazu Matsuoka |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Freund's Adjuvant Central nervous system Pain Exon Dorsal root ganglion Neurotrophic factors Ganglia Spinal Internal medicine medicine Animals RNA Messenger Ligation Molecular Biology Brain-derived neurotrophic factor Messenger RNA Lumbar Vertebrae business.industry Brain-Derived Neurotrophic Factor General Neuroscience Mononeuropathies Exons Spinal cord Rats Disease Models Animal Spinal Nerves medicine.anatomical_structure Endocrinology Spinal Cord nervous system Spinal nerve Neurology (clinical) business Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 1206:13-19 |
| ISSN: | 0006-8993 |
| Popis: | Brain-derived neurotrophic factor (BDNF) expression changes in the dorsal root ganglion (DRG) and spinal cord in some pain models. Recently, rat BDNF transcripts containing novel 5' untranslated exons were identified and characterized, and a new numbering system for rat BDNF exons was introduced. We examined the expression profiles of these novel BDNF transcripts in bilateral L4/5 DRGs in an L5-selective spinal nerve ligation (SSNL) model and bilateral L5 DRGs in a complete Freund's adjuvant (CFA) model of rats. L5SSNL increased significantly (P |
| Databáze: | OpenAIRE |
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