Breast cancer takes up 99mTc bombesin. A preliminary report
| Autor: | A. Pulcini, Francesco Scopinaro, Silvia Remediani, G. P. Evangelatos, Alexandra D. Varvarigou, R. Massa, W. Ussof, V.D. Corleto, Francesca Capoccetti, S. C. Archimandritis, G. De Vincentis |
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| Rok vydání: | 2002 |
| Předmět: |
Technetium Tc 99m Sestamibi
Cancer Research medicine.medical_treatment Breast Neoplasms Scintigraphy 030218 nuclear medicine & medical imaging 03 medical and health sciences breast cancer 0302 clinical medicine Breast cancer lymph nodes Prostate Predictive Value of Tests Breast-conserving surgery scintigraphy Medicine Humans Radionuclide Imaging Aged Scintimammography medicine.diagnostic_test business.industry General Medicine Middle Aged medicine.disease Primary tumor Up-Regulation Gene Expression Regulation Neoplastic Receptors Bombesin Technetium Compounds medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Exocrine pancreatic cancer Lymphadenectomy Bombesin Female bombesin technetium Radiopharmaceuticals business Nuclear medicine |
| Zdroj: | Tumori. 88(3) |
| ISSN: | 0300-8916 |
| Popis: | Background Several tumors including lung, prostate, ovarian, colon, and exocrine pancreatic cancer show receptors for the amphibian neurotransmitter and growth factor bombesin (BN) and its mammalian counterparts gastrin-releasing peptide and neuromedin B. Also breast cancer has been reported to show such receptors: the presence of BN receptors in primary breast cancer has been demonstrated on cultured cells and by autoradiography on breast tissue samples. Authors who have studied BN receptors in breast cancer do not agree on their frequency in primary cancer, but indicate that 100% of metastatic breast cancers show such receptors. Methods We examined three primary breast cancer patients with 99mTc BN and 99mTc sestamibi one week before surgery. One of them showed axillary node invasion. The same acquisition technique was used for breast and chest imaging with both radiopharmaceuticals, whereas total body images were acquired only with 99mTc BN. Also the administered radioactivity was different: 20 mCi of 99mTc sestamibi and 5-8 mCi of 99mTc BN. Dynamic images were acquired for 20 mins after iv injection with the patient in ventral decubitus and the gamma camera positioned in lateral view, as is generally done in Khakhali's prone scintimammography. Anterior chest images were acquired for 30 mins. Prone scintimammography was performed one hour after administration of both tracers. ROIs were drawn on tumors and surrounding breast with the same technique in order to calculate the tumor to breast ratio (T/B). In addition, total body scan was performed one hour and three hours after 99mTc BN administration. All three patients underwent breast conserving surgery with lymphadenectomy. Postoperative pathologic assessment showed the following T and N stages in the three patients: T1bN0, T1cN0. and T1cN1. Results All three cancers were imaged with both tracers. The T/B of 99mTc BN was always higher than that of 99mTc sestamibi. Chest uptake was always much higher with 99mTc sestamibi than with 99mTc BN. Comparison between 99mTc BN and 99mTc sestamibi images gave other intriguing results: in the N1 patient both tracers clearly imaged the invaded node, but on the 99mTc BN image the primary tumor was larger than on the 99mTc sestamibi image and the node was smaller. It is known that 99mTc BN is not taken up by vessels and inflammatory tissue. The time activity curves of the two tracers were significantly different in all patients, with an increase in 99mTc BN uptake in the first three to five minutes, followed by a less sharp uprise of the curve, quite similar to a plateau. Conclusions Our first impression is that 99mTc BN is a useful breast cancer seeking agent and very promising for lymph node staging. |
| Databáze: | OpenAIRE |
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