Pharmacokinetic evaluation of pancreatic arterial infusion chemotherapy with lipid emulsion as a drug carrier in an animal model
| Autor: | Feng Duan, Mao-Qiang Wang, Liu-Xin Duan, Peng Song, Guo-Kun Ao, Qiang Li |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Cancer Research
medicine.medical_specialty Fat Emulsions Intravenous Antineoplastic Agents Pharmacology Splenic artery Gastroenterology Group A Group B Dogs Pharmacokinetics Internal medicine medicine.artery Pancreatic cancer medicine Animals Infusions Intra-Arterial Pharmacology (medical) Pancreas Phospholipids Cisplatin Drug Carriers Chemistry medicine.disease Soybean Oil Pancreatic Neoplasms medicine.anatomical_structure Oncology Models Animal Emulsions Drug carrier Splenic Artery medicine.drug |
| Zdroj: | Anti-cancer drugs. 23(7) |
| ISSN: | 1473-5741 |
| Popis: | The purpose of this study was to investigate the potential pharmacokinetic advantage of pancreatic arterial infusion chemotherapy with lipid emulsion as a drug carrier for pancreatic cancer in a dog model. The 20% Intralipid, as a solvent, was used in the experimental animals with 2 ml/kg (group A) and 1 ml/kg (group B). Normal sodium as a solvent was used as a control with 2 ml/kg (group C) and 1 ml/kg (group D), respectively. Cisplatin (4 mg/kg) was infused into the proximal segment of the splenic artery. The concentrations of cisplatin were measured in plasma of the portal vein and in the liver and pancreas of groups A and C. The area under the concentration-time curve (AUC), the maximum plasma concentration (C(max)), and the elimination half-life (t(1/2)) in plasma were calculated and compared statistically. Compared with group C, the AUC and C(max) of group A were significantly lower (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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