DNA repair and immune checkpoint blockade response

Autor:	Jimmy A. Guo, Mohammed Alshalalfa, Daniel Y. Kim, Hannah I. Hoffman, Carina Shiau, Jennifer Su, William L. Hwang, Brandon A. Mahal
Rok vydání:	2022
Předmět:	Cancer Research Lung Neoplasms DNA Repair Carcinoma Non-Small-Cell Lung Biomarkers Tumor Genetics Humans Immune Checkpoint Inhibitors Molecular Biology
Zdroj:	Cancer Genetics. :1-4
ISSN:	2210-7762
Popis:	Immune checkpoint blockade (ICB) has shown immense promise for treating patients with various cancer types, but its effectiveness relies on our ability to identify likely responders. Here, we examined the association between mutations in 25 core DNA repair genes and ICB outcomes in 6619 patients across 9 cancer types with advanced disease and MSK-IMPACT tumor sequencing. Notably, we observed that mutations in 7 of the DNA repair genes (ATM, ATR, POLE, ERCC4, NBN, RAD50, PARP1) were significantly associated with improved overall survival in ICB-treated patients (p0.05 for all) and had significant interaction with treatment (p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd5b658af9c64f192b1b837141023bc1 https://doi.org/10.1016/j.cancergen.2022.02.007 Zobrazit plný text záznamu Full Text from ScienceDirect