Actin cytoskeleton in mesenchymal-to-amoeboid transition of cancer cells
| Autor: | Antonina Y. Alexandrova, Aleksandra S. Chikina, Tatyana Svitkina |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0303 health sciences
Cell signaling 030302 biochemistry & molecular biology Cell migration Biology Actin cytoskeleton Models Biological Article Cell biology Extracellular matrix 03 medical and health sciences Actin Cytoskeleton Cell Movement Neoplasms Cancer cell Animals Humans Bleb (cell biology) Lamellipodium Neoplasm Metastasis Cytoskeleton |
| Zdroj: | Int Rev Cell Mol Biol International Review of Cell and Molecular Biology ISBN: 9780128212837 |
| ISSN: | 1937-6448 |
| Popis: | During development of metastasis, tumor cells migrate through different tissues and encounter different extracellular matrices. An ability of cells to adapt mechanisms of their migration to these diverse environmental conditions, called migration plasticity, gives tumor cells an advantage over normal cells for long distant dissemination. Different modes of individual cell motility—mesenchymal and amoeboid—are driven by different molecular mechanisms, which largely depend on functions of the actin cytoskeleton that can be modulated in a wide range by cellular signaling mechanisms in response to environmental conditions. Various triggers can switch one motility mode to another, but regulations of these transitions are incompletely understood. However, understanding of the mechanisms driving migration plasticity is instrumental for finding anti-cancer treatment capable to stop cancer metastasis. In this review, we discuss cytoskeletal features, which allow the individually migrating cells to switch between mesenchymal and amoeboid migrating modes, called mesenchymal-to-amoeboid transition (MAT). We briefly describe main characteristics of different cell migration modes, and then discuss the triggering factors that initiate MAT with special attention to cytoskeletal features essential for migration plasticity. |
| Databáze: | OpenAIRE |
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