Expression of platelet-derived growth factor B is upregulated in patients with thoracic aortic dissection
| Autor: | Zonghong Liu, Shangdian Liu, Hongyu Liu, Hui Yang, Weixin Meng, Bo Sun, Dandan Li |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Male Pathology medicine.medical_specialty PDGFRB Inflammation Aorta Thoracic 030204 cardiovascular system & hematology Vascular Remodeling Collagen Type I Extracellular matrix Receptor Platelet-Derived Growth Factor beta 03 medical and health sciences 0302 clinical medicine Vascular Stiffness Fibrosis medicine.artery Ascending aorta Medicine Humans Aorta biology Aortic Aneurysm Thoracic business.industry Proto-Oncogene Proteins c-sis Middle Aged medicine.disease Elastic Tissue Up-Regulation Aortic Dissection 030104 developmental biology Case-Control Studies biology.protein Surgery Female medicine.symptom Cardiology and Cardiovascular Medicine business Elastin Homeostasis Biomarkers |
| Zdroj: | Journal of vascular surgery. 68(6S) |
| ISSN: | 1097-6809 |
| Popis: | Objective Thoracic aortic dissection (TAD) is a serious condition requiring urgent treatment to avoid catastrophic consequences. The inflammatory response is involved in the occurrence and development of TAD, possibly potentiated by platelet-derived growth factors (PDGFs). This study aimed to determine whether expression of PDGF-B (a subunit of PDGF-BB) was increased in TAD patients and to explore the factors responsible for its upregulation and subsequent effects on TAD. Methods Full-thickness ascending aorta wall specimens from TAD patients (n = 15) and control patients (n = 10) were examined for expression of PDGF-B and its receptor (PDGFRB) and in terms of morphology, inflammation, and fibrosis. Blood samples from TAD and control patients were collected to detect plasma levels of PDGF-BB and soluble elastins. Results Expression levels of PDGF-B, PDGFRB, and collagen I were significantly enhanced in ascending aorta wall specimens from TAD patients compared with controls. Furthermore, soluble elastic fragments and PDGF-BB were significantly increased in plasma from TAD patients compared with controls, and numerous irregular elastic fibers and macrophages were seen in the ascending aorta wall in TAD patients. Conclusions An increase in elastic fragments in the aorta wall might be responsible for inducing the activation and migration of macrophages to injured sites, leading to elevated expression of PDGF-B, which in turn induces deposition of collagen, disrupts extracellular matrix homeostasis, and increases the stiffness of the aorta wall, resulting in compromised aorta compliance. |
| Databáze: | OpenAIRE |
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