A Multifunctional Subphthalocyanine Nanosphere for Targeting, Labeling, and Killing of Antibiotic-Resistant Bacteria
| Autor: | Jeesu Kim, Indranil Roy, Kangkyun Baek, Sandro Kappert, Raghunandan Hota, Kimoon Kim, Dinesh K. Shetty, Chulhong Kim |
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| Rok vydání: | 2015 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Indoles medicine.medical_treatment Photodynamic therapy Nanotechnology Microbial Sensitivity Tests Isoindoles Fluorescence Catalysis Structure-Activity Relationship chemistry.chemical_compound Escherichia coli medicine Particle Size chemistry.chemical_classification Photosensitizing Agents Dose-Response Relationship Drug Molecular Structure biology Drug Resistance Microbial General Chemistry Polymer General Medicine biology.organism_classification Combinatorial chemistry Anti-Bacterial Agents Monomer chemistry Covalent bond Self-assembly Phototoxicity Nanospheres Bacteria |
| Zdroj: | Angewandte Chemie. 127:15367-15370 |
| ISSN: | 0044-8249 |
| Popis: | Developing a material that can combat antibiotic-resistant bacteria, a major global health threat, is an urgent requirement. To tackle this challenge, we synthesized a multifunctional subphthalocyanine (SubPc) polymer nanosphere that has the ability to target, label, and photoinactivate antibiotic-resistant bacteria in a single treatment with more than 99 % efficiency, even with a dose as low as 4.2 J cm(-2) and a loading concentration of 10 nM. The positively charged nanosphere shell composed of covalently linked SubPc units can increase the local concentration of photosensitizers at therapeutic sites. The nanosphere shows superior performance compared to corresponding monomers presumably because of their enhanced water dispersibility, higher efficiency of singlet-oxygen generation, and phototoxicity. In addition, this material is useful in fluorescence labeling of living cells and shows promise in photoacoustic imaging of bacteria in vivo. |
| Databáze: | OpenAIRE |
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