Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia
| Autor: | Stephen M. Lawrie, Emma Neilson, Heather C. Whalley, Eve C. Johnstone, Catherine Bois, Andrew M. McIntosh, David G. C. Owens, Victoria Barker |
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| Rok vydání: | 2016 |
| Předmět: |
Male
Social Work medicine.medical_specialty Population Hippocampus Hippocampal formation Amygdala Functional Laterality Young Adult 03 medical and health sciences 0302 clinical medicine mental disorders Image Processing Computer-Assisted medicine Humans Family Genetic Predisposition to Disease Longitudinal Studies Prospective Studies Young adult Prospective cohort study education Psychiatry Biological Psychiatry education.field_of_study Organ Size medicine.disease Magnetic Resonance Imaging 030227 psychiatry Psychiatry and Mental health medicine.anatomical_structure Adult Survivors of Child Adverse Events Schizophrenia Cohort Female Psychology Stress Psychological 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Barker, V, Bois, C, Neilson, E, Johnstone, E C, Owens, D, Whalley, H, McIntosh, A & Lawrie, S 2016, ' Childhood adversity and hippocampal and amygdala volumes in a population at familial high risk of schizophrenia ', Schizophrenia Research . https://doi.org/10.1016/j.schres.2016.04.028 |
| ISSN: | 0920-9964 |
| DOI: | 10.1016/j.schres.2016.04.028 |
| Popis: | Background There is an established link between childhood adversity (CA) and schizophrenia. Hippocampus and amygdala abnormalities pre-date onset in those at high familial risk (fHR) of schizophrenia, but it is not clear whether these alterations are associated with CA in those at elevated risk of schizophrenia. Methods We examined hippocampal and amygdala volumes in those at fHR who had been referred to a social worker or the Children's Panel compared to those who had not. Results The right hippocampus and left amygdala were significantly smaller in those that had been referred to social work and Children's Panel. Conclusions Our findings suggest that CA can influence structural changes in the brain in a cohort at fHR of schizophrenia. These findings provide further evidence that while genetic factors contribute to the structural changes found in schizophrenia, environmental factors such as CA can have a lasting impact on specific brain regions. |
| Databáze: | OpenAIRE |
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