Nanoimprinted multifunctional nanoprobes for a homogeneous immunoassay in a top-down fabrication approach
| Autor: | Barbara Schmid, Pia Schneeweiss, Astrit Shoshi, Joerg Schotter, Michael Muehlberger, Hubert Brueckl, Stefan Schrittwieser, Tina Mitteramskogler, Michael J. Haslinger |
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| Rok vydání: | 2021 |
| Předmět: |
Fabrication
Materials science Science Dispersity Physics::Optics Nanoparticle Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Article Nanoimprint lithography law.invention Magnetic properties and materials law Thin film Anisotropy Sensors and probes Plasmon Multidisciplinary Nanofabrication and nanopatterning 021001 nanoscience & nanotechnology 0104 chemical sciences Biosensors Homogeneous Medicine Nanoparticles 0210 nano-technology Diagnostic devices |
| Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Multifunctional nanoparticles are discussed as versatile probes for homogeneous immunoassays for in-vitro diagnostics. Top-down fabrication allows to combine and tailor magnetic and plasmonic anisotropic properties. The combination of nanoimprint lithography, thin film deposition, and lift-off processing provides a top-down fabrication platform, which is both flexible and reliable. Here, we discuss the material compositions and geometrical designs of monodisperse multicomponent nanoparticles and their consequences on optical and magnetic properties. The rotational hydrodynamics of nanoparticles is measured and considered under the influence of magnetic shape anisotropy in the framework of the Stoner-Wohlfarth theory. The plasmon-optical properties are explained by discrete-dipole finite-element simulations. Rotational dynamical measurements of imprinted nanoprobes for two test proteins demonstrate the applicability as highly sensitive biomolecular nanoprobes. |
| Databáze: | OpenAIRE |
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