The anti-genotoxic effect of some lichenic acids
| Autor: | Guleray Agar, Hamit Emre Kizil, Ozel Capik, Selcuk Ceker |
|---|---|
| Přispěvatelé: | Belirlenecek, Bayburt University |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Gel electrophoresis
vulpinic acid Multidisciplinary Chromatography Vulpinic acid DNA damage lichen compounds Antigenotoxic activity Cell Lobaric acid lecanoric acid In vitro Comet assay chemistry.chemical_compound lobaric acid medicine.anatomical_structure chemistry Carbon tetrachloride medicine diffractaic acid |
| Popis: | Four lichen secondary metabolites; diffractaic acid, lecanoric acid, lobaric acid and vulpinic acid were evaluated for the anti-genotoxic effects on human lymphocytes in vitro using single cell gel electrophoresis (SCGE) or comet assay. Carbon tetrachloride, a known mutagenic agent was used as the positive control in the comet test system. The results revealed that at all concentrations, the tested compounds mediated a significant decrease in total DNA damage (comet assay) as compared with positive controls (p > 0.05). The most effective doses of lichen acids were found to be 100 ?gmL-1 of diffractic acid, lobaric acid and vulpinic acid, and 50 ?gmL-1 of lecanoric acid. In addition, it was determined that the most effective among the tested compounds was vulpinic acid. © 2018, National Science Foundation. All rights reserved. |
| Databáze: | OpenAIRE |
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