Bifidobacterium longum with Fructo-Oligosaccharide (FOS) Treatment in Minimal Hepatic Encephalopathy: A Randomized, Double-Blind, Placebo-Controlled Study
| Autor: | Filippo Greco, Gloria Barone, Michele Malaguarnera, Maria Antonietta Toscano, Mariano Malaguarnera, Maria Pia Gargante |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Cirrhosis Bifidobacterium longum Physiology Encephalopathy Oligosaccharides Neuropsychological Tests Placebo Gastroenterology Double-Blind Method Liver Function Tests Ammonia Internal medicine medicine Humans Aspartate Aminotransferases Hepatic encephalopathy medicine.diagnostic_test biology business.industry Probiotics Alanine Transaminase Neuropsychological test Middle Aged medicine.disease biology.organism_classification Treatment Outcome Endocrinology Hepatic Encephalopathy Bifidobacterium Fructo-oligosaccharides Chronic Disease Drug Therapy Combination Female Liver function Liver function tests business Follow-Up Studies |
| Zdroj: | Digestive Diseases and Sciences. 52:3259-3265 |
| ISSN: | 1573-2568 0163-2116 |
| Popis: | Minimal hepatic encephalopathy (MHE) describes patients with chronic liver disease or cirrhosis who have no clinical symptoms of brain dysfunction but perform worse on psychometric tests compared with healthy subjects. The pathogenesis of hepatic encephalopathy is controversial although ammonia has been found to induce cerebral dysfunction. Increased intestinal ammonia production is due to bacterial urease activity and the production of other toxin methabolities, such as mercaptans, thioles. This study assesses the clinical efficacy of Bifidobacterium longum plus fructo-oligosaccharides (FOS) in the treatment of MHE. A total of 60 cirrhotic patients were randomly and equally divided into two groups receiving Bifidobacterium+FOS (17 males, 13 females; mean age, 46+/-11 years) or placebo (16 males, 14 females; mean age, 45+/-12 years), respectively. All patients underwent clinical and laboratory assessment psychometric tests and automated EEG analysis: neurophysiological assessment, liver function assessment, amd neuropsychological assessment. After 90 days of treatment, fasting NH(4) serum levels were significantly decreased (P=0.003), performance on Trail Making Test-A was significantly decreased (P=0.000), performance on Trail Making Test-B was significantly decreased (P=0.000), performance on the symbol digit modalities test was significantly improved (P |
| Databáze: | OpenAIRE |
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