Prevention of the rehaemorrhage of bleeding peptic ulcers: effects of Helicobacter pylori eradication and acid suppression

Autor:	S. Tsunada, Yasuhisa Sakata, Ryuichi Iwakiri, A. Kikkawa, Akifumi Ootani, Hiroyuki Sakata, Kazuma Fujimoto, S. Amemori, T. Koyama, T. Fujise, H. Ootani
Rok vydání:	2005
Předmět:	Adult Male medicine.medical_specialty Spirillaceae Peptic Peptic Ulcer Hemorrhage Gastroenterology Group A Group B Helicobacter Infections Internal medicine Secondary Prevention Medicine Humans Pharmacology (medical) Aged Aged 80 and over Hepatology biology Helicobacter pylori business.industry Hemostasis Endoscopic Antagonist Proton Pump Inhibitors Middle Aged biology.organism_classification Anti-Bacterial Agents Famotidine Histamine H2 Antagonists Drug Therapy Combination Female Antacids business medicine.drug
Zdroj:	Alimentary pharmacologytherapeutics. 21
ISSN:	0269-2813
Popis:	Summary Aim : This study aimed to investigate the consequences of Helicobacter pylori eradication and acid suppression on rehaemorrhage caused by bleeding peptic ulcers. Methods : A total of 320 patients who had been diagnosed with bleeding peptic ulcers between January 1994 and December 2001 were included in the study. Cases between 1994 and 1997, prior to the introduction of eradication therapy, were assigned to group A, whereas those between 1998 and 2001, after the eradication therapy, were assigned to group B. Results : Of the 320 cases, 162 were designated as group A (113 gastric ulcers and 49 duodenal ulcers) and 158 as group B (116 and 42, respectively). Rehaemorrhage occurred in 24 cases (15%) and five cases (3%) in groups A and B, respectively, presenting a significantly decreased rate of rehaemorrhage in group B. Among those without eradication, rehaemorrhage was observed in 15 of 128 cases (12%) that received treatment with histamine2-receptor antagonist (famotidine), and 14 of 142 cases (10%) treated with proton-pump inhibitors, with no significant difference between the two. Conclusions : Helicobacter pylori eradication lowered the rates of rehaemorrhage. Treatment with histamine2-receptor antagonist or proton-pump inhibitors did not produce a difference in the rate of rehaemorrhage.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd4ee1df7113bc66d7884354e8a59f4d https://pubmed.ncbi.nlm.nih.gov/15943852 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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