| Autor: |
Yuya Ohno, Chikako Nakajima, Itsuki Ajioka, Takahiro Muraoka, Atsuya Yaguchi, Teppei Fujioka, Saori Akimoto, Misaki Matsuo, Ahmed Lotfy, Sayuri Nakamura, Vicente Herranz-Pérez, José Manuel García-Verdugo, Noriyuki Matsukawa, Naoko Kaneko, Kazunobu Sawamoto |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Zdroj: |
Ohno, Yuya Nakajima, Chikako Ajioka, Itsuki Muraoka, Takahiro Yaguchi, Atsuya Fujioka, Teppei Akimoto, Saori Matsuo, Misaki Lofty, Ahmed Nakamura, Sayuri Herranz Pérez, Vicente García Verdugo, José Manuel Matsukawa, Noriyuki Kaneko, Naoko Sawamoto, Kazunobu 2023 Amphiphilic peptide-tagged N-cadherin forms radial glial-like fibers that enhance neuronal migration in injured brain and promote sensorimotor recovery Biomaterials 294 122003 1 17 |
| Popis: |
The mammalian brain has very limited ability to regenerate lost neurons and recover function after injury. Promoting the migration of young neurons (neuroblasts) derived from endogenous neural stem cells using biomaterials is a new and promising approach to aid recovery of the brain after injury. However, the delivery of sufficient neuroblasts to distant injured sites is a major challenge because of the limited number of scaffold cells that are available to guide neuroblast migration. To address this issue, we have developed an amphiphilic peptide [(RADA)3-(RADG)] (mRADA)-tagged N-cadherin extracellular domain (Ncad-mRADA), which can remain in mRADA hydrogels and be injected into deep brain tissue to facilitate neuroblast migration. Migrating neuroblasts directly contacted the fiber-like Ncad-mRADA hydrogel and efficiently migrated toward an injured site in the striatum, a deep brain area. Furthermore, application of Ncad-mRADA to neonatal cortical brain injury efficiently promoted neuronal regeneration and functional recovery. These results demonstrate that self- assembling Ncad-mRADA peptides mimic both the function and structure of endogenous scaffold cells and provide a novel strategy for regenerative therapy. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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