Crosstalk between the nociceptive and immune systems in host defence and disease
| Autor: | David L.H. Bennett, Stephen B. McMahon, Federica La Russa |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
animal diseases
Pain chemical and pharmacologic phenomena Disease Biology Adaptive Immunity Host Specificity Immune system Animals Humans Organism Immunity Cellular Innate immune system General Neuroscience Nociceptors biochemical phenomena metabolism and nutrition Acquired immune system Immunity Innate Crosstalk (biology) Nociception Signalling nervous system Immune System Diseases Immune System Immunology bacteria Neuroscience |
| Zdroj: | Nature reviews. Neuroscience. 16(7) |
| ISSN: | 1471-0048 |
| Popis: | Nociceptors and immune cells both protect the host from potential threats to homeostasis. There is growing evidence for bidirectional signalling between these two systems, and the underlying mechanisms are beginning to be elucidated. An understanding is emerging of how both the adaptive and innate immune systems can activate and sensitize nociceptors, and, reciprocally, how nociceptors modulate immune cells. In this Review, we discuss how these interactions can be adaptive and useful to the organism but also consider when such signalling might be maladaptive and pathophysiological, contributing to immune-mediated diseases and persistent pain states. |
| Databáze: | OpenAIRE |
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