Depressed Leukotriene B 4 Chemotactic Response of Neutrophils from Localized Juvenile Periodontitis Patients
| Autor: | Bonnie M. Odle, Thomas E. Van Dyke, Steven S. Scott, S. Offenbacher, Carolyn Wilson-Burrows |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Adult
medicine.medical_specialty Neutrophils Leukotriene B4 Peptide Biology chemistry.chemical_compound Internal medicine Juvenile periodontitis medicine Humans Aggressive periodontitis Periodontal Diseases chemistry.chemical_classification hemic and immune systems Chemotaxis respiratory system N-Formylmethionine leucyl-phenylalanine medicine.disease In vitro N-Formylmethionine Leucyl-Phenylalanine Chemotaxis Leukocyte stomatognathic diseases Endocrinology Aggressive Periodontitis chemistry Immunology Periodontics lipids (amino acids peptides and proteins) |
| Zdroj: | Journal of Periodontology. 58:602-606 |
| ISSN: | 1943-3670 0022-3492 |
| DOI: | 10.1902/jop.1987.58.9.602 |
| Popis: | Previous studies have demonstrated that certain local juvenile periodontitis (LJP) patients possess neutrophils with an intrinsic chemotactic defect to the peptide chemoattractants f-met-leu-phe (FMLP) and C5a. In this investigation, the in vitro response of neutrophils to the chemotactic agent leukotriene B4 (LTB4) was examined. Those LJP patients who possessed defective chemotactic responses to FMLP and endotoxin activated serum (EAS) also had impaired chemotaxis to LTB4. Exogenous LTB4 failed to augment the impaired response to FMLP. Evidence for a global membrane defect in LJP neutrophils resulting in hyporesponsiveness to chemically diverse chemotactic agents is presented. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text