Effect of local application of delmopinol hydrochloride on developing and early established supragingival plaque in humans
| Autor: | Rolf Attström, Lars Matsson, T. Sjodin, Stig Edwardsson, Björn Klinge |
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| Předmět: |
Male
Cuspid Hydrochloride Administration Topical Morpholines Colony Count Microbial Dental Plaque Gingiva Dentistry Placebo Dental plaque Oral hygiene Placebos chemistry.chemical_compound Bacteria Anaerobic Surface-Active Agents medicine Humans Bicuspid Cross-Over Studies Bacteria business.industry Dental Plaque Index Tooth surface Streptococcus Buccal administration medicine.disease Oral Hygiene Crossover study chemistry Periodontics Streptococcus sanguis business |
| Zdroj: | Karolinska Institutet CIÊNCIAVITAE |
| Popis: | The aim of the study was to investigate the effect of delmopinol hydrochloride on the development of dental plaque and on newly established plaque. In addition, the influence of this compound on the composition of the microbiota colonizing the gingival mucous membrane was studied. 14 healthy male volunteers took part. After a 3 week pre-experimental period of intense oral hygiene, the participants refrained from all oral hygiene for 14 days. The buccal surfaces of cuspids and bicuspids on one side of the jaws were treated with a 1% aqueous solution of delmopinol hydrochloride (applied with a paint brush) 2 x a day for 7 days, while the contralateral side received placebo solution. On day 7, the application procedures were changed in that the test compound was applied on the teeth previously treated with placebo and vice versa. Plaque development was assessed clinically and by photo-based planimetric determination. The clinical recordings revealed that 89.3% of the placebo-treated surfaces displayed visible plaque on day 7, compared to 6.0% of the delmopinol hydrochloride treated surfaces. Delmopinol hydrochloride treatment of the previously placebo-treated surfaces resulted in a decrease in the number of surfaces with visible plaque from 89.3% on day 7 to 6% on day 14. These results were confirmed by the planimetric data. No significant change in the composition of the mucosal flora was observed during the experimental period. The present results indicate that delmopinol hydrochloride markedly reduces the formation of dental plaque on a clean tooth surface exposed to conditions which favour bacterial colonization. Furthermore, the substance appears to possess plaque-dissolving properties. |
| Databáze: | OpenAIRE |
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