A Plastic β-Tricalcium Phosphate/Gelatine Scaffold Seeded with Allogeneic Adipose-Derived Stem Cells for Mending Rabbit Bone Defects
| Autor: | Jane Smith, Peng Zhou, Chunxia Huang, Saiqun Xu, Jia Liu |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Calcium Phosphates
Scaffold Biocompatibility Adipose tissue Biology Osteogenesis Animals Transplantation Homologous Cells Cultured Bone mineral β tricalcium phosphate Tissue Scaffolds Rabbit (nuclear engineering) Cell Differentiation Mesenchymal Stem Cells Cell Biology Bone defect Gelatin Female Rabbits Stem cell Bone Diseases Plastics Developmental Biology Biotechnology Biomedical engineering Stem Cell Transplantation |
| Zdroj: | Cellular reprogramming. 23(1) |
| ISSN: | 2152-4998 |
| Popis: | To investigate the feasibility of β-tricalcium phosphate (TCP)/gelatine scaffold combined with allogeneic adipose-derived stem cells (ASCs) to repair hole shape defect, third-passage ASCs were seeded onto composite scaffolds to prepare an ASC-β-TCP/gelatine tissue-engineered bone to pack into the rabbit cavernous bone defects of experimental groups. In animal models, the bone defect area was completely filled and difficult to recognize in the experimental group at 12 weeks post-surgery by gross observation and radiographic examination. The average bone mineral density value of them was higher than that of the control group. Because of the biocompatibility with allogenic ASCs and the osteoconductivity of β-TCP/gelatine scaffolds, β-TCP/gelatine is suitable as a plastic scaffold for the ASC-seeded tissue-engineered bone to repair cavernous defects. |
| Databáze: | OpenAIRE |
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