Effect of disc degeneration on the mechanical behavior of the human lumbar spine: a probabilistic finite element study
| Autor: | Sandra Reitmaier, Maxim Bashkuev, Hendrik Schmidt |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Facet (geometry)
Finite Element Analysis 0206 medical engineering Context (language use) Intervertebral Disc Degeneration 02 engineering and technology Degeneration (medical) Lumbar vertebrae 03 medical and health sciences 0302 clinical medicine medicine Humans Orthopedics and Sports Medicine Range of Motion Articular Intervertebral Disc Lumbar Vertebrae Models Statistical business.industry Stiffness Intervertebral disc 020601 biomedical engineering Finite element method Biomechanical Phenomena medicine.anatomical_structure Ligament Surgery Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery Biomedical engineering |
| Zdroj: | The Spine Journal. 18:1910-1920 |
| ISSN: | 1529-9430 |
| DOI: | 10.1016/j.spinee.2018.05.046 |
| Popis: | BACKGROUND CONTEXT Intervertebral disc degeneration has been subject to numerous in vivo and in vitro investigations and numerical studies during recent decades, reporting partially contradictory findings. However, most of the previous studies were limited in the number of specimens investigated and, therefore, could not consider the vast variety of the specimen geometries, which are likely to strongly influence the mechanical behavior of the spine. PURPOSE To complement the understanding of the mechanical consequences of disc degeneration, whereas considering natural variations in the major spinal geometrical parameters. DESIGN/SETTING A probabilistic finite element study. METHODS A parametric finite element model of a human L4–L5 motion segment considering 40 geometrical parameters was developed. One thousand individual geometries comprising four degeneration grades were generated in a probabilistic manner, and the influence of the severity of disc degeneration on the mechanical response of the motion segment to different loading conditions was statistically evaluated. RESULTS Variations in the individual structural parameters resulted in marked variations in all evaluated parameters within each degeneration grade. Nevertheless, the effect of degeneration in almost all evaluated response values was statistically significant. With degeneration, the intradiscal pressure progressively decreased. At the same time, the facet loads increased and the ligament tension was reduced. The initially nonlinear load-deformation relationships became linear whereas the segment stiffness increased. CONCLUSIONS Results indicate significant stiffening of the motion segment with progressing degeneration and gradually increasing loading of the facets from nondegenerated to moderately degenerated conditions along with a significant reduction of the ligament tension in flexion. |
| Databáze: | OpenAIRE |
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