Prevalence of dyslipidaemia among HIV-infected patients receiving combination antiretroviral therapy in North Shewa, Ethiopia
Autor: | Henok Dereje, Angesom Gebreweld, Temesgen Fiseha, Zemenu Tamir, Worku Alemu |
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Rok vydání: | 2021 |
Předmět: |
RNA viruses
CD4-Positive T-Lymphocytes Male Rural Population Urban Population Human immunodeficiency virus (HIV) Blood lipids HIV Infections Cardiovascular Medicine 030204 cardiovascular system & hematology Pathology and Laboratory Medicine Logistic regression medicine.disease_cause Biochemistry 0302 clinical medicine Immunodeficiency Viruses Antiretroviral Therapy Highly Active Medicine and Health Sciences Prevalence Hiv infected patients Public and Occupational Health 030212 general & internal medicine Aged 80 and over Multidisciplinary Middle Aged Vaccination and Immunization Lipids Lipid Profiles Cholesterol Medical Microbiology Cardiovascular Diseases Viral Pathogens Viruses Medicine Infectious diseases lipids (amino acids peptides and proteins) Female Pathogens Research Article Medical conditions Adult medicine.medical_specialty Adolescent Anti-HIV Agents Science Lipoproteins Immunology Cardiology Antiretroviral Therapy Viral diseases Microbiology 03 medical and health sciences Antiviral Therapy Internal medicine Retroviruses medicine Humans In patient Microbial Pathogens Triglycerides Aged Dyslipidemias business.industry Lentivirus Cholesterol HDL Background data Organisms Biology and Life Sciences HIV Proteins Cholesterol LDL Cardiovascular Disease Risk Antiretroviral therapy CD4 Lymphocyte Count Cross-Sectional Studies Logistic Models Preventive Medicine Ethiopia High ratio business |
Zdroj: | PLoS ONE PLoS ONE, Vol 16, Iss 4, p e0250328 (2021) |
ISSN: | 1932-6203 |
Popis: | Background Data on the burden of dyslipidaemia among people with HIV undergoing antiretroviral therapy (ART) in sub-Saharan Africa are limited and little is known about the factors contributing for poor lipid profiles. The aim of this study was to determine the prevalence of dyslipidaemia and factors associated with lipid levels among HIV-infected patients receiving first-line combination ART in North Shewa, Ethiopia. Methods A cross-sectional study was conducted between April and December 2018 among 392 HIV-infected adults receiving first-line ART for at least six months at the ART clinic of Mehal Meda Hospital in North Shewa, Ethiopia. Blood samples were collected for determination of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and CD4 counts. Logistic regression analysis was used to determine factors associated with lipid abnormalities. Results The prevalence of dyslipidaemia was 59.9% (95% CI 55.0–64.7%). High TC, high TG, low HDL-c, and high LDL-c were obtained in 47.3%, 30.9%, 19.4% and 29.6%, respectively. Fifty-four participants (13.8%) had high ratio of TC/HDL-c (TC/HDL-c ratio ≥ 5). Older age was independently associated with high TC (AOR = 2.51, 95% CI 1.64–3.84), high TG (AOR = 2.95, 95% CI 1.85–4.71), low HDL–c (AOR = 2.02, 95% CI 1.17–3.50), and high LDL–c (AOR = 3.37, 95% CI 2.08–5.47). Living in an urban area (AOR = 2.61, 95% CI 1.16–6.14) and smoking (AOR = 3.61, 95% CI 1.06–12.34) were associated with low HDL–c. Participants with longer duration of ART use were more likely to have high TG (AOR = 1.86, 95% CI: 1.13–3.07), low HDL–c (AOR = 3.47, 95% CI: 1.75–6.80), and high LDL–c (AOR = 2.20, 95% CI 1.30–3.71). High BMI was independently associated with higher TC (AOR = 2.43, 95% CI 1.19–4.97), high TG (AOR = 4.17, 95% CI 2.01–8.67) and high LDL–c (AOR = 6.53, 95% CI 3.05–13.98). Conclusions We found a high prevalence of dyslipidaemia among HIV-infected patients receiving first-line ART in North Shewa, Ethiopia. There is a need for monitoring of blood lipid levels in patients with HIV on long term first-line ART with a special attention to be focused on older age, urban residents, longer duration of ART use, high BMI and smokers. |
Databáze: | OpenAIRE |
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