Prevalence of dyslipidaemia among HIV-infected patients receiving combination antiretroviral therapy in North Shewa, Ethiopia

Autor: Henok Dereje, Angesom Gebreweld, Temesgen Fiseha, Zemenu Tamir, Worku Alemu
Rok vydání: 2021
Předmět:
RNA viruses
CD4-Positive T-Lymphocytes
Male
Rural Population
Urban Population
Human immunodeficiency virus (HIV)
Blood lipids
HIV Infections
Cardiovascular Medicine
030204 cardiovascular system & hematology
Pathology and Laboratory Medicine
Logistic regression
medicine.disease_cause
Biochemistry
0302 clinical medicine
Immunodeficiency Viruses
Antiretroviral Therapy
Highly Active
Medicine and Health Sciences
Prevalence
Hiv infected patients
Public and Occupational Health
030212 general & internal medicine
Aged
80 and over
Multidisciplinary
Middle Aged
Vaccination and Immunization
Lipids
Lipid Profiles
Cholesterol
Medical Microbiology
Cardiovascular Diseases
Viral Pathogens
Viruses
Medicine
Infectious diseases
lipids (amino acids
peptides
and proteins)
Female
Pathogens
Research Article
Medical conditions
Adult
medicine.medical_specialty
Adolescent
Anti-HIV Agents
Science
Lipoproteins
Immunology
Cardiology
Antiretroviral Therapy
Viral diseases
Microbiology
03 medical and health sciences
Antiviral Therapy
Internal medicine
Retroviruses
medicine
Humans
In patient
Microbial Pathogens
Triglycerides
Aged
Dyslipidemias
business.industry
Lentivirus
Cholesterol
HDL
Background data
Organisms
Biology and Life Sciences
HIV
Proteins
Cholesterol
LDL
Cardiovascular Disease Risk
Antiretroviral therapy
CD4 Lymphocyte Count
Cross-Sectional Studies
Logistic Models
Preventive Medicine
Ethiopia
High ratio
business
Zdroj: PLoS ONE
PLoS ONE, Vol 16, Iss 4, p e0250328 (2021)
ISSN: 1932-6203
Popis: Background Data on the burden of dyslipidaemia among people with HIV undergoing antiretroviral therapy (ART) in sub-Saharan Africa are limited and little is known about the factors contributing for poor lipid profiles. The aim of this study was to determine the prevalence of dyslipidaemia and factors associated with lipid levels among HIV-infected patients receiving first-line combination ART in North Shewa, Ethiopia. Methods A cross-sectional study was conducted between April and December 2018 among 392 HIV-infected adults receiving first-line ART for at least six months at the ART clinic of Mehal Meda Hospital in North Shewa, Ethiopia. Blood samples were collected for determination of total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-c), low-density lipoprotein cholesterol (LDL-c), and CD4 counts. Logistic regression analysis was used to determine factors associated with lipid abnormalities. Results The prevalence of dyslipidaemia was 59.9% (95% CI 55.0–64.7%). High TC, high TG, low HDL-c, and high LDL-c were obtained in 47.3%, 30.9%, 19.4% and 29.6%, respectively. Fifty-four participants (13.8%) had high ratio of TC/HDL-c (TC/HDL-c ratio ≥ 5). Older age was independently associated with high TC (AOR = 2.51, 95% CI 1.64–3.84), high TG (AOR = 2.95, 95% CI 1.85–4.71), low HDL–c (AOR = 2.02, 95% CI 1.17–3.50), and high LDL–c (AOR = 3.37, 95% CI 2.08–5.47). Living in an urban area (AOR = 2.61, 95% CI 1.16–6.14) and smoking (AOR = 3.61, 95% CI 1.06–12.34) were associated with low HDL–c. Participants with longer duration of ART use were more likely to have high TG (AOR = 1.86, 95% CI: 1.13–3.07), low HDL–c (AOR = 3.47, 95% CI: 1.75–6.80), and high LDL–c (AOR = 2.20, 95% CI 1.30–3.71). High BMI was independently associated with higher TC (AOR = 2.43, 95% CI 1.19–4.97), high TG (AOR = 4.17, 95% CI 2.01–8.67) and high LDL–c (AOR = 6.53, 95% CI 3.05–13.98). Conclusions We found a high prevalence of dyslipidaemia among HIV-infected patients receiving first-line ART in North Shewa, Ethiopia. There is a need for monitoring of blood lipid levels in patients with HIV on long term first-line ART with a special attention to be focused on older age, urban residents, longer duration of ART use, high BMI and smokers.
Databáze: OpenAIRE
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