Understanding the role of antibodies in murine infections withHeligmosomoides(polygyrus)bakeri: 35 years ago, now and 35 years ahead
| Autor: | Nicola L. Harris, Richard J. Pleass, J. M. Behnke |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Protective immunity
Immunology Antibodies Helminth Host-Parasite Interactions Mice 03 medical and health sciences 0302 clinical medicine Hygiene hypothesis Immunity Animals Humans Parasite hosting Intestinal Diseases Parasitic Nematode Infections Disease Resistance Immune Evasion 030304 developmental biology Nematospiroides dubius 0303 health sciences biology biology.organism_classification 3. Good health Disease Models Animal Chronic Disease biology.protein Parasitology Intestinal nematode Heligmosomoides polygyrus Antibody 030215 immunology |
| Zdroj: | Parasite immunology |
| ISSN: | 0141-9838 |
| DOI: | 10.1111/pim.12057 |
| Popis: | The rodent intestinal nematode H.p.bakeri has played an important role in the exploration of the host-parasite relationship of chronic nematode infections for over six decades, since the parasite was first isolated in the 1950s by Ehrenford. It soon became a popular laboratory model providing a tractable experimental system that is easy to maintain in the laboratory and far more cost-effective than other laboratory nematode-rodent model systems. Immunity to this parasite is complex, dependent on antibodies, but confounded by the parasite's potent immunosuppressive secretions that facilitate chronic survival in murine hosts. In this review, we remind readers of the state of knowledge in the 1970s, when the first volume of Parasite Immunology was published, focusing on the role of antibodies in protective immunity. We show how our understanding of the host-parasite relationship then developed over the following 35 years to date, we propose testable hypotheses for future researchers to tackle, and we speculate on how the new technologies will be applied to enable an increasingly refined understanding of the role of antibodies in host-protective immunity, and its evasion, to be achieved in the longer term. |
| Databáze: | OpenAIRE |
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