Effects of fish oil on oxidation resistance of VLDL in hypertriglyceridemic patients
| Autor: | Hans M.G. Princen, W. Onkenhout, Eric J.G. Sijbrands, A. van der Laarse, Augustinus H. M. Smelt, W. van Duyvenvoorde, A.J.G.H. Bindels, M.F. Hau |
|---|---|
| Přispěvatelé: | Gaubius Instituut TNO |
| Jazyk: | angličtina |
| Rok vydání: | 1996 |
| Předmět: |
Male
Very low-density lipoprotein oral drug administration lipid blood level Lipoproteins VLDL alpha tocopherol fish oil VLDL oxidation fatty acid blood level low density lipoprotein cholesterol chemistry.chemical_compound lipid oxidation high density lipoprotein cholesterol hyperlipidemia chemistry.chemical_classification clinical article omega-3 fatty acids article Middle Aged Fish oil polyunsaturated fatty acid very low density lipoprotein cholesterol fat intake priority journal diet supplementation lipids (amino acids peptides and proteins) triacylglycerol Cardiology and Cardiovascular Medicine Polyunsaturated fatty acid Adult medicine.medical_specialty hypertriglyceridemia omega 3 fatty acid lipoprotein blood level digestive system Fish Oils Lipid oxidation Internal medicine medicine Humans human Omega 3 fatty acid Biology Triglyceride Cholesterol cholesterol Diet Endocrinology chemistry Lipid Peroxidation LDL oxidation Lipoprotein |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology, 9, 16, 1197-1202 Scopus-Elsevier CIÊNCIAVITAE |
| Popis: | In hypertriglyceridemic (HTG) patients the addition of fish oil to the diet causes a marked reduction in the concentration of triglyceride-rich lipoproteins in the serum. To investigate the effects of fish oil on the oxidation resistance of VLDL and LDL in HTG patients, nine male patients received 1 g/d fish oil (containing 55.7% n-3 polyunsaturated fatty acids [PUFAs] and 1 U α-tocopherol/g fish oil) for 6 weeks followed by 5 g/d fish oil for an additional 6 weeks. Cu 2+ -induced oxidation of VLDL and LDL was measured by continuous monitoring of conjugated dienes. Supplementation with 1 g/d fish oil caused hardly any changes in the n-3 PUFA content of lipoproteins or lipoprotein concentrations in serum. However, supplementation with 5 g/d fish oil resulted in a significant increase of n-3 PUFA content in VLDL (from 2.5% to 6.4% of total fatty acids) and LDL (from 3.2% to 6.4% of total fatty acids), decreases in serum triglyceride, VLDL triglyceride, and VLDL cholesterol concentrations of 54%, 56%, and 40%, respectively, and an increase in LDL cholesterol of 23%. The lag times of VLDL and LDL oxidation decreased from 197 to 140 minutes (−29%) and 101 to 86 minutes (−15%), respectively. At the end of the 5 g/d fish oil supplementation the lag times of VLDL and LDL oxidation were correlated with their respective n-3 PUFA content ( r =−.67; P r =−.79; P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|