Effect of lycopene on testicular androgenic and anti-oxidative enzymes in cyproterone acetate-induced male infertile Wistar strain albino rats: An in vitro study
| Autor: | Debidas Ghosh, Prabal Ghosh, Farhin Ara, Adrija Tripathy |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Antioxidant 3-Hydroxysteroid Dehydrogenases 17-Hydroxysteroid Dehydrogenases Urology medicine.medical_treatment Drug Evaluation Preclinical medicine.disease_cause Male infertility Superoxide dismutase chemistry.chemical_compound Endocrinology Lycopene Internal medicine Testis medicine Animals Humans heterocyclic compounds Rats Wistar Cyproterone Acetate Infertility Male Glutathione Transferase Peroxidase biology Sperm Count business.industry Superoxide Dismutase Cyproterone acetate General Medicine Free Radical Scavengers medicine.disease Catalase Rats Disease Models Animal Oxidative Stress chemistry Toxicity cardiovascular system biology.protein Androgens business Oxidative stress |
| Zdroj: | AndrologiaREFERENCES. 52(3) |
| ISSN: | 1439-0272 |
| Popis: | Incidents of male infertility are mushrooming worldwide. Oxidative stress plays a prime role for its onset. Considering this background, the study was designed to focus the direct role of lycopene on cyproterone acetate (CPA) induced testicular hypofunction in rat. Four groups have been considered including the vehicle-treated control, lycopene-treated control, CPA-treated and CPA+ lycopene-treated groups. Androgenic, antioxidant and toxicity profiles were assessed. Results focused a nonsignificant (p > .05) difference in recovery of testicular Δ5 , 3β-hydroxysteroid dehydrogenase (HSD), 17β-HSD after direct exposure of lycopene compared to the CPA-treated group. On other side, lycopene exposure to the testicular tissue of CPA-treated rat (CPA+ lycopene-treated) exhibited a significant (p |
| Databáze: | OpenAIRE |
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