Associations of Fetal Growth Outcomes with Measures of the Combined Xenoestrogenic Activity of Maternal Serum Perfluorinated Alkyl Acids in Danish Pregnant Women
| Autor: | Manhai Long, Eva Cecilie Bonefeld-Jørgensen, Jørn Olsen, Bodil Hammer Bech, Christian Bjerregaard-Olesen, Tine Brink Henriksen, Maria Wielsøe, Cathrine Carlsen Bach |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Denmark Fluorocarbons/adverse effects Health Toxicology and Mutagenesis Physiology Endocrine Disruptors 010501 environmental sciences 01 natural sciences Fetal Development Cohort Studies Head/growth & development 0302 clinical medicine Pregnancy Fetal growth Birth Weight Body Size Medicine 030212 general & internal medicine Receptor chemistry.chemical_classification Fluorocarbons Fetal Development/drug effects Receptors Estrogen Prenatal Exposure Delayed Effects language Female Receptors Estrogen/metabolism Cohort study Adult Transcriptional Activation Birth weight Body Size/drug effects Transfection Danish 03 medical and health sciences Cell Line Tumor Humans Estrogen Metabolism Alkyl 0105 earth and related environmental sciences Endocrine Disruptors/adverse effects business.industry Research Infant Newborn Public Health Environmental and Occupational Health Pregnancy/blood Denmark/epidemiology language.human_language chemistry Birth Weight/drug effects business Head |
| Zdroj: | Olesen, C B, Bach, C C, Long, M, Wielsøe, M, Bech, B H, Henriksen, T B, Olsen, J & Bonefeld-Jørgensen, E C 2019, ' Associations of fetal growth outcomes with measures of the combined xenoestrogenic activity of maternal serum perfluorinated alkyl acids in Danish pregnant women ', Environmental Health Perspectives, vol. 127, no. 1, 17006 . https://doi.org/10.1289/EHP1884 Environmental Health Perspectives |
| ISSN: | 1552-9924 0091-6765 |
| DOI: | 10.1289/ehp1884 |
| Popis: | BACKGROUND:Higher concentrations of single perfluorinated alkyl acids (PFAAs) have been associated with lower birth weight (BW), but few studies have examined the combined effects of PFAA mixtures. PFAAs have been reported to induce estrogen receptor (ER) transactivity, and estrogens may influence human fetal growth. We hypothesize that mixtures of PFAAs may affect human fetal growth by disrupting the ER.OBJECTIVES:We aimed to study the associations between the combined xenoestrogenic activity of PFAAs in pregnant women's serum and offspring BW, length, and head circumference.METHODS:We extracted the actual mixture of PFAAs from the serum of 702 Danish pregnant women (gestational wk 11-13) enrolled in the Aarhus Birth Cohort (ABC) using solid phase extraction, high-performance liquid chromatography (HPLC), and weak anion exchange. PFAA-induced xenoestrogenic receptor transactivation (XER) was determined using the stable transfected MVLN cell line. Associations between XER and measures of fetal growth were estimated using multivariable linear regression with primary adjustment for maternal age, body mass index (BMI), educational level, smoking, and alcohol intake, and sensitivity analyses with additional adjustment for gestational age (GA) (linear and quadratic).RESULTS:On average, an interquartile range (IQR) increase in XER was associated with a [Formula: see text] [95% confidence interval (CI): [Formula: see text], [Formula: see text]] decrease in BW and a [Formula: see text] (95% CI: 0.1, 0.5) decrease in birth length. Upon additional adjustment for GA, the estimated mean differences were [Formula: see text] (95% CI: [Formula: see text], 4) and [Formula: see text] (95% CI: [Formula: see text], 0.0), respectively.CONCLUSION:Higher-serum PFAA-induced xenoestrogenic activities were associated with lower BW and length in offspring, suggesting that PFAA mixtures may affect fetal growth by disrupting ER function. https://doi.org/10.1289/EHP1884. |
| Databáze: | OpenAIRE |
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