Increased Prevalence of Human Polyomavirus JC Viruria in Chronic Inflammatory Rheumatic Diseases Patients in Treatment with Anti-TNF α: A 18 Month Follow-Up Study
| Autor: | Rossana Scrivo, Anna Bellizzi, Gianlorenzo Conte, Valeria Pietropaolo, Anna Teresa Palamara, Elena Anzivino, Maria Trancassini, Guido Valesini, Daniela Scribano, Carla Prezioso, Donatella Maria Rodio, Monica Mischitelli |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Population lcsh:QR1-502 Viremia chronic inflammatory rheumatic diseases Microbiology lcsh:Microbiology anti-TNF- α 03 medical and health sciences 0302 clinical medicine Medicine VP1 NCCR education Genotyping Original Research 030203 arthritis & rheumatology human polyomavirus JC education.field_of_study business.industry Incidence (epidemiology) Progressive multifocal leukoencephalopathy medicine.disease Virology anti-TNF-α 030104 developmental biology Immunology Etiology business Viral load Rheumatism |
| Zdroj: | Frontiers in Microbiology, Vol 7 (2016) Frontiers in Microbiology |
| ISSN: | 1664-302X |
| DOI: | 10.3389/fmicb.2016.00672 |
| Popis: | Chronic inflammatory rheumatic diseases (CIRDs) are immune-mediated pathologies involving joints. To date, TNFα-blocking agents administration is the most promising therapy, although these treatments are associated with an increased Polyomavirus JC (JCPyV) reactivation, the etiological agent of the Progressive Multifocal Leukoencephalopathy (PML). The aim of this study was the recruitment and the analysis of a CIRDs cohort in order to investigate a possible correlation between JCPyV presence and the influence of anti-TNF-α agents on viral loads. Blood and urine samples were collected from 34 CIRDs subjects prior the first anti-TNF-α infusion (T0) and after 3 (T3), 6 (T6), 12 (T12), and 18 (T18) months. Results showed persistent JC viruria significantly higher than JC viremia throughout the 18 month follow-up study (p = 0.002). In JCPyV positive samples, the non-coding control region (NCCR) was analyzed. Results evidenced archetypal structures (type II-S) in all isolates with the exception of a sequence isolated from a plasma sample, that corresponds to the type II-R found in PML subjects. Finally, the viral protein 1 (VP1) genotyping was performed and results showed the prevalence of the European genotypes 1A, 1B, and 4. Since only few studies have been carried out to understand whether there is a PML risk in CIRDs population infected by JCPyV, this study contributes to enrich literature insight on JCPyV biology in this cluster. Further investigations are necessary in order to recognize the real impact of biologics on JCPyV life cycle and to identify possible and specific viral variants related to increased virulence in CIRDs patients. |
| Databáze: | OpenAIRE |
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