Low‐Pressure Cobalt‐Catalyzed Enantioselective Hydrovinylation of Vinylarenes
| Autor: | Sohajl Movahhed, Mehmet Dindaroğlu, Julia Westphal, Hans-Günther Schmalz, Anna Falk |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Ethylene
010405 organic chemistry Ligand Organic Chemistry Enantioselective synthesis chemistry.chemical_element Regioselectivity General Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Catalysis 0104 chemical sciences Broad spectrum chemistry.chemical_compound chemistry Organic chemistry Chirality (chemistry) Cobalt |
| Zdroj: | Chemistry – A European Journal. 22:7381-7384 |
| ISSN: | 1521-3765 0947-6539 |
| DOI: | 10.1002/chem.201601283 |
| Popis: | An efficient and practical protocol for the enantioselective cobalt-catalyzed hydrovinylation of vinylarenes with ethylene at low (1.2 bar) pressure has been developed. As precatalysts, stable [L2 CoCl2 ] complexes are employed that are activated in situ with Et2 AlCl. A modular chiral TADDOL-derived phosphine-phosphite ligand was identified that allows the conversion of a broad spectrum of substrates, including heterocyclic vinylarenes and vinylferrocene, to smoothly afford the branched products with up to 99 % ee and virtually complete regioselectivity. Even polar functional groups, such as OH, NH2 , CN, and CO2 R, are tolerated. |
| Databáze: | OpenAIRE |
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