Synthesis and antibacterial activities of novel oxazolidinones having spiro[2,4]heptane moieties

Autor:	Chang-Hyun Oh, Jung-Hyuck Cho, So-Young Kim, Hyeong Beom Park, Kyung Ho Yoo
Rok vydání:	2009
Předmět:	Stereochemistry Chemistry Pharmaceutical Clinical Biochemistry Pharmaceutical Science Microbial Sensitivity Tests Ring (chemistry) Gram-Positive Bacteria Biochemistry Chemical synthesis Heptanes chemistry.chemical_compound Methicillin Structure-Activity Relationship Vancomycin Drug Discovery Drug Resistance Bacterial Gram-Negative Bacteria Molecular Biology Oxazolidinones Antibacterial agent Heptane Molecular Structure Organic Chemistry Biological activity Oxime Anti-Bacterial Agents chemistry Models Chemical Drug Design Molecular Medicine Antibacterial activity
Zdroj:	Bioorganicmedicinal chemistry letters. 19(9)
ISSN:	1464-3405
Popis:	The synthesis of a new series of oxazolidinones having spiro[2,4]heptane moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituents on the oxazolidinone ring was investigated. A particular compound Ih having fluoro group showed the most potent antibacterial activity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd3c37e1aa50fb3d19185e09324042a8 https://pubmed.ncbi.nlm.nih.gov/19345578 Zobrazit plný text záznamu Full Text from ScienceDirect