Magnetic nanoparticle-loaded electrospun polymeric nanofibers for tissue engineering
| Autor: | XianLun Pang, Biqiong Wang, HaiSu Wan, Jingbo Wu, Linglin Yang, Shaozhi Fu, Jiyi Xia, Ming Zhao, Heng Zhang |
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| Rok vydání: | 2017 |
| Předmět: |
Materials science
Cell Survival Polymers Polyesters Nanofibers Nanoparticle Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 01 natural sciences Polyethylene Glycols Nanomaterials Biomaterials Mice chemistry.chemical_compound X-Ray Diffraction Spectroscopy Fourier Transform Infrared Animals Magnetite Nanoparticles Calorimetry Differential Scanning Tissue Engineering Hydrolysis Temperature 021001 nanoscience & nanotechnology Electrospinning 0104 chemical sciences Membrane Microscopy Fluorescence chemistry Chemical engineering Mechanics of Materials Nanofiber Drug delivery NIH 3T3 Cells Magnetic nanoparticles 0210 nano-technology Iron oxide nanoparticles |
| Zdroj: | Materials Science and Engineering: C. 73:537-543 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.12.116 |
| Popis: | Magnetic nanoparticles have been one of the most attractive nanomaterials for various biomedical applications including magnetic resonance imaging (MRI), diagnostic contrast enhancement, magnetic cell separation, and targeted drug delivery. Three-dimensional (3-D) fibrous scaffolds have broad application prospects in the biomedical field, such as drug delivery and tissue engineering. In this work, a novel three-dimensional composite membrane composed of the tri-block copolymer poly(e-caprolactone)-poly(ethylene glycol)-poly(e-caprolactone) (PCL-PEG-PCL, PCEC) and magnetic iron oxide nanoparticles (Fe3O4 NPs) were fabricated using electrospinning technology. The physico-chemical properties of the PCEC/Fe3O4 membranes were investigated by Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Morphological observation using scanning electron microscopy (SEM) showed that the composite fibers containing 5% Fe3O4 nanoparticles had a diameter of 250nm. In vitro cell culture of NIH 3T3 cells on the PCEC/Fe3O4 membranes showed that the PCEC/Fe3O4 fibers might be a suitable scaffold for cell adhesion. Moreover, MTT analysis also demonstrated that the membranes possessed lower cytotoxicity. Therefore, this study revealed that the magnetic PCEC/Fe3O4 fibers might have great potential for using in skin tissue engineering. |
| Databáze: | OpenAIRE |
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