Enhanced tumor necrosis factor alpha in coronavirus but not in paracetamol-induced acute hepatic necrosis in mice
| Autor: | Michelle Hadchouel, Marc Tardieu, G. Sebire, Didier Decimo, D. Devictor |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Pathology mice Coronaviridae Infections tumor necrosis factor Fulminant coronavirus medicine.disease_cause Gastroenterology Pathogenesis Internal medicine medicine Animals hepatitis Fulminant hepatitis Acetaminophen Coronavirus Hepatitis Hepatology Tumor Necrosis Factor-alpha business.industry Alanine Transaminase medicine.disease Pathophysiology Hepatic Encephalopathy Hepatitis Viral Animal Original Article Tumor necrosis factor alpha Chemical and Drug Induced Liver Injury business medicine.drug |
| Zdroj: | Liver |
| ISSN: | 0106-9543 |
| Popis: | Previous reports have demonstrated that tumor necrosis factor alpha (TNF-alpha) plays an important role in the pathogenesis of fulminant hepatic necrosis. The purpose of this experimental study was to measure TNF-alpha blood activity in paracetamol-induced liver necrosis and in coronavirus (MHV3)-induced fulminant hepatitis in mice. No elevation of TNF-alpha activity was found in hepatic failure complicating paracetamol poisoning. In contrast, TNF-alpha activity significantly increased in response to MHV3, reaching 16.3 +/- 5.5 U/ml from 24 h post infection (P less than 0.01). This augmentation was observed even though the virus was not detectable in the liver. Serum alanine aminotransferase levels were low and no histological lesion was observed. In conclusion, our study further supports the implication of TNF-alpha in virus-induced hepatitis failure and confirms that paracetamol poisoning does not cause increased TNF-alpha activity in the circulation. |
| Databáze: | OpenAIRE |
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