Positive association between a DNA sequence variant in the serotonin 2A receptor gene and schizophrenia
| Autor: | Toru Ishida, Yasuhiro Inayama, Hiroyuki Asaba, Jun Koh, Hiroshi Yoneda, Yoshihiro Kono, Ryuichi Takahata, Toshiaki Sakai, Akiko Takai, Jun Sakai, Y. Inada, Yasuhiro Nonomura |
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| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Psychosis Molecular Sequence Data Biology Gene mutation behavioral disciplines and activities Gene mapping mental disorders medicine Humans Receptor Serotonin 5-HT2A Genetics (clinical) 5-HT receptor Genetic association Chromosome 13 DNA Primers Genetics Base Sequence DNA Middle Aged medicine.disease Schizophrenia Receptors Serotonin Female Restriction fragment length polymorphism Polymorphism Restriction Fragment Length |
| Zdroj: | American journal of medical genetics. 67(1) |
| ISSN: | 0148-7299 |
| Popis: | Sixty-two patients with schizophrenia and 96 normal controls were investigated for genetic association with restriction fragment length polymorphisms (RFLPs) in the serotonin receptor genes. A positive association between the serotonin 2A receptor gene (HTR2A) and schizophrenia was found, but not between schizophrenia and the serotonin 1A receptor gene. The positive association we report here would suggest that the DNA region with susceptibility to schizophrenia lies in the HTR2A on the long arm of chromosome 13. © 1996 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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