What is myeloperoxidase doing in ANCA-associated glomerulonephritis?
| Autor: | William G. Couser, Richard J. Johnson |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Pathology
medicine.medical_specialty Anca associated glomerulonephritis animal diseases Severity of injury Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis urologic and male genital diseases Antibodies Antineutrophil Cytoplasmic Glomerulonephritis Antigen medicine Humans Peroxidase biology business.industry Hydrogen Peroxide Cytoplasmic antibody medicine.disease Nephrology Myeloperoxidase Immunology biology.protein Antibody business Vasculitis |
| Zdroj: | Kidney International. 88:938-940 |
| ISSN: | 0085-2538 |
| Popis: | O'Sullivan et al. describe glomerular localization of myeloperoxidase (MPO) in anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and correlate the amount of deposition with severity of injury. MPO is the antigen against which anti-MPO ANCAs are directed, the antigen to which pathogenic T cells that can induce antibody-independent AAV are directed, and MPO can induce glomerular injury directly by interacting with H2O2 and a halide to halogenate glomerular structures. All three of these roles are likely involved in human disease. |
| Databáze: | OpenAIRE |
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