Processing of sentinel lymph nodes for detection of metastatic melanoma
| Autor: | Sandra H. Clark, Victor G. Prieto |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Pathology
medicine.medical_specialty Metastatic melanoma Sentinel Lymph Node Biopsy business.industry Melanoma medicine.medical_treatment Decision Trees Sentinel lymph node Cancer General Medicine medicine.disease Immunohistochemistry Pathology and Forensic Medicine Clinical Protocols Biomarkers Tumor Standard protocol Humans Medicine Lymphadenectomy Lymph Neoplasm Metastasis Breast carcinoma business |
| Zdroj: | Annals of Diagnostic Pathology. 6:257-264 |
| ISSN: | 1092-9134 |
| DOI: | 10.1053/adpa.2002.35400 |
| Popis: | Within the last years, evaluation of sentinel lymph nodes (SLN) has become the most popular method of early staging of several malignancies, including breast carcinoma and melanoma. Because SLN are reportedly the lymph nodes most likely to contain metastatic deposits, identification of such nodes allows pathologists to examine the tissue in a much more intense manner than with the usual lymphadenectomy specimens containing multiple lymph nodes. However, there is not a universally accepted standard protocol for pathologic processing of the SLN. Initially, the most popular protocols called for bisection of the SLN and examination of serial sections, with or without routinely performed immunohistochemistry. Lately, other protocols have been proposed to try to simplify the histologic analysis while providing at least equivalent results. Here we review the different protocols used for the evaluation of SLN and describe the protocol currently in use at M. D. Anderson Cancer Center (Houston, TX). |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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